57957-24-1

Basic information

• Product Name: N-(1-PHENYL-VINYL)-ACETAMIDE
• Synonyms: N-(1-PHENYL-VINYL)-ACETAMIDE;1-(Acetylamino)-1-phenylethene;N-(1-Phenylethenyl)acetamide;N-Acetyl-1-phenylethenamine;N-Acetyl-1-phenyletheneamine;N-(1-Phenylvinyl)
• CAS NO: 57957-24-1
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.20044
• Mol File: 57957-24-1.mol
• Article Data: 56

Chemical Properties

• Melting Point: 91-92℃
• Boiling Point: 359.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.022±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 15.01±0.46(Predicted)
• CAS DataBase Reference: N-(1-PHENYL-VINYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-PHENYL-VINYL)-ACETAMIDE(57957-24-1)
• EPA Substance Registry System: N-(1-PHENYL-VINYL)-ACETAMIDE(57957-24-1)

Safety Data

• Hazardous Substances Data: 57957-24-1(Hazardous Substances Data)

Upstream product

• 52762-80-8 N-(1-phenylethylidene)acetamide 
• 16717-64-9 1-azidostyrene 
• 108-24-7 acetic anhydride 
• 52762-80-8 N-(α-methylbenzylidene)acetamide 
• 117194-13-5 N-<1-phenyl-2-(2-pyridylseleno)ethyl>acetamide 
• 75-16-1 methylmagnesium bromide 
• 100-47-0 benzonitrile 
• 75-36-5 acetyl chloride 
• 613-91-2 acetophenone oxime 
• 5202-78-8 acetylaminoethylene 
• 17763-67-6 Phenyl triflate 
• 98-86-2 acetophenone 
• 117194-06-6 1-phenyl-2-(2-pyridylseleno)ethanol 
• 96818-33-6 2-(2-Methoxy-2-phenyl-ethylselanyl)-pyridine 

Downstream Products

• 36283-44-0 N-acetyl-1-phenylethylamine 
• 19144-86-6 (S)-N-acetyl-1-phenylethylamine 
• 6284-14-6 N-acetyl-1-phenylethylamine 
• 399041-11-3 (2R)-2-dodecanoylamino-4-oxo-4-phenylbutyric acid ethyl ester hydrochloride 
• 36065-27-7 N-α-phenylethylacetamide 
• 35883-55-7 methyl 2,3-diphenylpyridine-6-carboxylate 
• 107393-03-3 α-Phenylisocinchomeronic acid dimethyl ester 
• 91875-49-9 (S)-N-(3-oxo-1,3-diphenylpropyl)benzamide 
• 91875-49-9 (R)-N-(3-oxo-1,3-diphenylpropyl)benzamide 

Relevant articles and documents

Visible-light-promoted olefinic trifluoromethylation of enamides with CF3SO2Na

A visible-light-promoted olefinic C-H trifluoromethylation of enamides was developed by employing cheap and stable Langlois’ reagent as the CF3source. A series of β-CF3enamides were obtained in moderate to good yields with highE-isomer selectivity under mild conditions. Preliminary mechanistic studies suggest that molecular oxygen acts as the terminal oxidant for this net oxidative process, and theEisomer selectivity could be well explained by a base-assisted deprotonation of the cation intermediate.

Access to multi-functionalized oxazolines via silver-catalyzed heteroannulation of enamides with sulfoxonium ylides

Disclosed herein is an efficient Ag-catalyzed [4 + 1] heteroannulation reaction of enamides with α-carbonyl sulfoxonium ylides. The diastereoselective transformation provides a practical access to a diverse range of multi-functionalized oxazoline derivatives. The synthetic utility of the resultant tetra-substituted oxazolines is further demonstrated by a series of useful manipulations into valuable building blocks of pharmaceutical relevance.

Fe(III)-catalyzed Oxidative Povarov Reaction with Molecular Oxygen Oxidant

The synthesis of tetrahydroquinoline derivatives from dimethyl anilines and enamides has been developed by Fe(III)-phenanthroline complex under aerobic condition. The oxidation of tertiary anilines involving a single electron transfer of Fe(phen)3(PF6)3 afforded the iminium ion intermediate, which reacted with electron-rich alkenes to build a six-membered N-heterocycles containing quaternary carbon center via the oxidative Povarov reaction process.