58022-21-2

Basic information

• Product Name: 1-ISOQUINOLIN-1-YL-ETHANONE
• Synonyms: 1-ISOQUINOLIN-1-YL-ETHANONE;Ethanone, 1-(1-isoquinolinyl)-;1-acetylisoquinoline;1-(Isoquinolin-1-yl)
• CAS NO: 58022-21-2
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.2
• Mol File: 58022-21-2.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 314.568 °C at 760 mmHg
• Flash Point: 152.033 °C
• Appearance: /
• Density: 1.154 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-ISOQUINOLIN-1-YL-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ISOQUINOLIN-1-YL-ETHANONE(58022-21-2)
• EPA Substance Registry System: 1-ISOQUINOLIN-1-YL-ETHANONE(58022-21-2)

Safety Data

• Hazardous Substances Data: 58022-21-2(Hazardous Substances Data)

Usage

General Description

1-ISOQUINOLIN-1-YL-ETHANONE is a chemical compound with the formula C11H9NO, and it belongs to the class of quinolinyl ketones. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. This chemical has a wide range of applications in the pharmaceutical industry, as it can be used as a building block in the production of drugs and other bioactive molecules. Additionally, it has been studied for its potential pharmacological properties, such as antimicrobial and anti-inflammatory effects. Overall, 1-ISOQUINOLIN-1-YL-ETHANONE is a versatile compound with important implications in the field of medicine and organic chemistry.

InChI:InChI=1/C11H9NO/c1-8(13)11-10-5-3-2-4-9(10)6-7-12-11/h2-7H,1H3

Upstream product

• 1198-30-7 1-isoquinolinecarbonitrile 
• 917-64-6 methyl magnesium iodide 
• 50458-78-1 ethyl isoquinoline-1-carboxylate 
• 141-78-6 ethyl acetate 
• 29924-67-2 2-acetyl-1,2-dihydro-isoquinoline-1-carbonitrile 
• 119-65-3 isoquinoline 
• 75-07-0 acetaldehyde 
• 74-88-4 methyl iodide 
• 86520-96-9 1-ethynylisoquinoline 
• 83629-90-7 1-trimethylstannyl-isoquinoline 
• 5704-66-5 pyruvoyl chloride 
• 111-34-2 -butyl vinyl ether 
• 123172-86-1 1-(trifluoromethanesulfonyloxy)isoquinoline 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 

Downstream Products

• 86726-73-0 1-cinnamoylisoquinoline 
• 5467-83-4 1-[1]isoquinolyl-1-phenyl-ethanol 
• 135765-67-2 C₂₀H₂₀N₆S₂ 
• 87555-66-6 methyl 3-<1-(1-isoquinolinyl)ethyl>hydrazinecarbodithioate 
• 87555-48-4 C₁₉H₂₄N₄S 
• 87555-46-2 C₁₉H₁₈N₄S 
• 87555-55-3 C₁₉H₂₆N₄S 
• 87555-53-1 C₁₉H₂₀N₄S 
• 87555-52-0 4-Phenyl-piperidine-1-carbothioic acid [1-isoquinolin-1-yl-eth-(Z)-ylidene]-hydrazide 
• 87555-61-1 4-Phenyl-piperidine-1-carbothioic acid N'-(1-isoquinolin-1-yl-ethyl)-hydrazide 
• 86733-99-5 4-Nitro-benzoic acid 3-phenyl-pyrrolo[2,1-a]isoquinolin-1-yl ester 
• 86726-74-1 1-hydroxy-3-phenyl-2-(1-phenylpyrrolo<2,1-a>isoquinolin-3-yl)-pyrrolo<2,1-a>isoquinoline 
• 1258282-77-7 methyl 1-acetylisoquinoline-4-carboxylate 

Relevant articles and documents

Highly chemoselective deoxygenation of N-heterocyclic: N -oxides under transition metal-free conditions

Because their site-selective C-H functionalizations are now considered one of the most useful tools for synthesizing various N-heterocyclic compounds, the highly chemoselective deoxygenation of densely functionalized N-heterocyclic N-oxides has received much attention from the synthetic chemistry community. Here, we provide a protocol for the highly chemoselective deoxygenation of various functionalized N-oxides under visible light-mediated photoredox conditions with Na2-eosin Y as an organophotocatalyst. Mechanistic studies imply that the excited state of the organophotocatalyst is reductively quenched by Hantzsch esters. This operationally simple technique tolerates a wide range of functional groups and allows high-yield, multigram-scale deoxygenation. This journal is

Carbonylative Acetylation of Heterocycles

Herein, a new procedure for the carbonylative acetylation of heterocycles has been developed. In this process, organic peroxide acts as the methyl source. Various heterocycles were transformed into the corresponding methyl heterocyclic ketones in moderate to good yields.

Iron-catalyzed Minisci acylation of N-heteroarenes with α-keto acids

An efficient and mild protocol has been developed for the Minisci acylation reactions of nitrogen-containing heteroarenes with α-keto acids. Distinct from the conventional Minisci acylation conditions, the chemistry was performed using non-noble metal Fe(II), instead of expensive Ag(I) salt, as catalyst. A wide range of substrates, including aliphatic or aromatic α-keto acids, as well as various N-heteroarenes, proved to be compatible with the protocol. Scale-up experiment also demonstrates the practicality of the approach.