58045-41-3Relevant articles and documents
Palladium(II) complexes of (t-butyl salicylidene) diphenyl disulfide diamine: synthesis, structure, spectral characterization and catalytic properties
Bhowon, Minu G.,Jhaumeer Laulloo, Sabina,Hosten, Eric C.,Elaheebacus, Sumayya,Dowlut, Mounisha R.
, p. 537 - 545 (2021)
The hexadentate N2S2O2 donor ligand N,N’-bis(3,5-tert-butylsalicylidene) diphenyl disulfide-2,2’-diamine was synthesised by the condensation of 2-aminophenyl disulfide and 3,5-di-tert-butyl-2-hydroxybenzaldehyde and its mo
Removal of soluble palladium complexes from reaction mixtures by fixed-bed adsorption
Girgis, Michael J.,Kuczynski, Laura E.,Berberena, Sonia M.,Boyd, Caitlin A.,Kubinski, Pamela L.,Scherhob, Megerle L.,Drinkwater, Donald E.,Shen, Xiaoxuan,Babiak, Stanislaw,Lefebvre, Brian G.
, p. 1209 - 1217 (2008)
The increasing use of metal-containing catalysts in producing pharmaceutical intermediates and active pharmaceutical ingredients, in conjunction with requirements of low metal content in a drug substance, has motivated the development of efficient separations processes for metals removal. In this paper, fixed-bed adsorption, an attractive alternative to batch adsorption, was investigated using a reaction mixture from a Heck coupling. Adsorption isotherm determinations using three candidate adsorbents revealed that QuadraPure TU had the greatest affinity and identified the optimal adsorption temperature. The bed residence time was key in obtaining good adsorption efficiency in subsequent fixed-bed experiments. Methods for palladium detection by HPLC were developed to monitor adsorption column performance in quasi real-time. A preliminary design methodology was developed in which actual breakthrough time is estimated from the experimentally determined tradeoff between bed efficiency and residence time. Even at the realized 55% bed efficiency, fixed-bed adsorption requires less than one-fourth the adsorbent needed for a single-stage batch adsorption process.
Pd salen complex@CPGO as a convenient, effective heterogeneous catalyst for Suzuki–Miyaura and Heck–Mizoroki cross-coupling reactions
Ghabdian, Mahdieh,Nasseri, Mohammad Ali,Allahresani, Ali,Motavallizadehkakhky, Alireza
, p. 1713 - 1728 (2018/05/25)
A Pd(II) Schiff base complex supported on graphene oxide nanosheets (Pd(II) salen@CPGO) has been synthesized and characterized by FT-IR, ICP-AES, XRD, SEM/EDX and TEM. The synthesized nanocatalyst has been found to be an efficient heterogeneous catalyst for Suzuki–Miyaura and Heck–Mizoroki coupling reactions. Pd(II) salen@CPGO could be separated and recovered easily from the reaction mixture and recycled several times without a discernible decrease in its catalytic activity. The construction of a solid sheet-supported Pd catalyst would be expected to be a promising system to perform heterogeneous catalytic reactions.
HISTONE DEACETYLASE 6 INHIBITORS AND METHOD FOR TREATING NEUROPATHIC PAIN
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Paragraph 0068; 0082-0083, (2021/01/29)
Disclosed herein are hydroxamic acid compounds. Also disclosed is a method of using the hydroxamic acid compounds for treating a condition associated with histone deacetylase 6.