5805-83-4

Basic information

• Product Name: 1H-Benzimidazole, 2-methyl-1-(phenylmethyl)-
• Synonyms: 1-benzyl-2-methyl-1H-benzoimidazole;1-benzyl-2-methylbenzoimidazole;1-benzyl-2-methylbenzimidazole
• CAS NO: 5805-83-4
• Molecular Formula: C15H14N2
• Molecular Weight: 222.29
• Mol File: 5805-83-4.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazole, 2-methyl-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole, 2-methyl-1-(phenylmethyl)-(5805-83-4)
• EPA Substance Registry System: 1H-Benzimidazole, 2-methyl-1-(phenylmethyl)-(5805-83-4)

Safety Data

• Hazardous Substances Data: 5805-83-4(Hazardous Substances Data)

Usage

Chemical Class

1H-Benzimidazole

Usage

Building block for the synthesis of pharmaceuticals and agrochemicals, production of dyes, pigments, and specialty chemicals, development of new materials and technologies

Potential Hazards

May pose hazards to human health and the environment if not managed properly.

Upstream product

• 615-15-6 2-Methyl-1H-benzimidazole 
• 100-44-7 benzyl chloride 
• 1493-27-2 ortho-nitrofluorobenzene 
• 100-46-9 benzylamine 
• 14321-27-8 N-ethylbenzylamine 
• 64-17-5 ethanol 
• 5729-06-6 N-benzyl-2-nitroaniline 
• 95-54-5 1,2-diamino-benzene 
• 533-17-5 N-(2-chlorophenyl)acetamide 
• 615-43-0 2-iodophenylamine 
• 60-35-5 acetamide 
• 76464-99-8 N-benzyl-2-iodoaniline 
• 5822-13-9 N-benzyl-1,2-phenylenediamine 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 90817-75-7 1-Benzyl-2-methyl-3-(p-nitrophenacyl)benzimidazolium Bromide 
• 191097-60-6 3,4,5,7-tetra-O-benzyl-1-[2-(1-benzyl)benzimidazolyl]-1-deoxy-α-D-gluco-2-heptulopyranose 
• 191097-77-5 acetyl-3,4,5,7-tetra-O-benzyl-1-[2-(1-benzyl)benzimidazolyl]-1-deoxy-α-D-gluco-2-heptulopyranoside 

Relevant articles and documents

Methanol as the C1source: Redox coupling of nitrobenzenes and alcohols for the synthesis of benzimidazoles

We present an operationally simple redox coupling for the synthesis of N-1 substituted benzimidazoles using feedstock building block 2-nitroaniline derivatives as the precursors and methanol as the C1 source. Higher atom, step, and redox economies and exc

Metal-free oxidative decarbonylative halogenation of fused imidazoles

An efficient strategy has been developed for the deformylative halogenation of carbaldehyde imidazo-fused heterocycles in the presence of TBHP controlled by temperature. A convenient and sequential functionalization (C8 to C3) portrays the synthetic utility of the current method.N-Heterocycle benzamide products were also observedviathe ring opening of imidazopyridines through the cleavage of C-C bond at high temperatures. Features of this method include temperature-controlled excellent regioselectivity, mild conditions and functional group tolerance.

Benzimidazole compound with endothelial lipase inhibition effect and application of benzimidazole compound

The invention discloses a benzimidazole compound with an endothelial lipase inhibition effect and application of the benzimidazole compound, and belongs to the technical field of medicines. The benzimidazole compound has an excellent inhibition effect on endothelial lipase, can effectively treating atherosclerosis and sequelae thereof, such as coronary heart disease, and also promotes treatment onmetabolic syndrome and sequelae thereof, such as diabetes. The benzimidazole compound provided by the invention has good solubility in an aqueous medium, also has good biological activity and metabolic stability, and shows advantages in the aspect of serum stability.