581-97-5

Basic information

• Product Name: B-ACETAMIDONAPHTHALENE
• Synonyms: 2-acetamidonaphthalene;Acetamide,N-2-naphthalenyl-;Acetamide,N-2-naphthyl-;beta-acetamidonaphthalide;n-2-naphthalenyl-acetamid;n-2-naphthalenylacetamide;n-2-naphthyl-acetamid;N-Acetyl-β-naphthylamine
• CAS NO: 581-97-5
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.22184
• EINECS: 209-476-6
• Product Categories: Aromatics, Intermediates, Miscellaneous Reagents
• Mol File: 581-97-5.mol
• Article Data: 82

Chemical Properties

• Melting Point: 240-241 °C
• Boiling Point: 413.6°Cat760mmHg
• Flash Point: 245.6°C
• Appearance: /
• Density: 1.182g/cm³
• Vapor Pressure: 2.78E-07mmHg at 25°C
• Refractive Index: 1.648
• PKA: 15.12±0.30(Predicted)
• CAS DataBase Reference: B-ACETAMIDONAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: B-ACETAMIDONAPHTHALENE(581-97-5)
• EPA Substance Registry System: B-ACETAMIDONAPHTHALENE(581-97-5)

Safety Data

• Hazardous Substances Data: 581-97-5(Hazardous Substances Data)

Usage

Description

B-ACETAMIDONAPHTHALENE is a chemical compound that has been utilized in the synthesis of novel phenyl pyrazolone-substituted 1H-benzo[g]pyrazolo[3,4-b]quinoline-3-ylamine derivatives. These derivatives have demonstrated significant antituberculosis and antibacterial properties, making B-ACETAMIDONAPHTHALENE a valuable precursor in the development of new antimicrobial agents.

Uses

Used in Pharmaceutical Industry:
B-ACETAMIDONAPHTHALENE is used as a precursor in the synthesis of novel phenyl pyrazolone-substituted 1H-benzo[g]pyrazolo[3,4-b]quinoline-3-ylamine derivatives for their antituberculosis and antibacterial activities. These derivatives have shown potential in combating drug-resistant strains of tuberculosis and various bacterial infections, highlighting the importance of B-ACETAMIDONAPHTHALENE in the development of new antimicrobial therapies.

InChI:InChI=1/C12H11NO/c13-12(14)8-9-5-6-10-3-1-2-4-11(10)7-9/h1-7H,8H2,(H2,13,14)

Upstream product

• 100485-52-7 2-acetonaphthone oxime 
• 51410-53-8 N-[2]naphthyl glycolamide 
• 108-24-7 acetic anhydride 
• 20986-24-7 [2]naphthylamine; compound with 1,3,5-trinitro-benzene 
• 91-59-8 naphthalen-2-ylamine 
• 71-43-2 benzene 
• 64-19-7 acetic acid 
• 631-61-8 ammonium acetate 
• 135-19-3 β-naphthol 
• 13114-62-0 2-naphthylcarbamide 
• 75-36-5 acetyl chloride 
• 463-51-4 Ketene 
• 507-09-5 thioacetic acid 
• 625-77-4 N-acetylacetamide 

Downstream Products

• 109747-02-6 2-(7-acetylamino-[1]naphthoyl)-benzoic acid 
• 7597-73-1 N-(1-bromonaphthalen-2-yl)acetamide 
• 582-19-4 (3-fluoro-phenyl)-[2]naphthyl-amine 
• 111033-94-4 N-[2]naphthyl-acetamide; compound with 2.4.6-trinitro-toluene 
• 606-57-5 1-nitro-2-naphthylamine 
• 50878-03-0 N-(5,6,7,8-tetrahydronaphth-2-yl)acetamide 
• 2217-43-8 6-amino-1,2,3,4-tetrahydronaphthalene 
• 86-60-2 7-aminonaphthalene-1-sulfonic acid 
• 81-05-0 6-aminonaphthalene-1-sulfonic acid 
• 861057-12-7 N-(1,6-dinitro-[2]naphthyl)-acetamide 
• 64574-27-2 N-(1,8-dinitro-[2]naphthyl)-acetamide 
• 3230-35-1 6-nitro-2-naphthylamine 
• 102877-11-2 2-Acetamido-6-nitro-naphthalin 
• 5419-82-9 1-nitro-2-acetylaminonaphthalene 

Relevant articles and documents

ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF

Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.

Method for promoting acylation of amine or alcohol by carbon dioxide

The invention relates to a method for promoting acylation of amine or alcohol by carbon dioxide, which comprises the following steps of: mixing an amine compound, carboxylate or thiocarboxylate compound and a reaction solvent under the action of carbon dioxide, and reacting to obtain an amide compound, or under the action of carbon dioxide, mixing the alcohol compound, the thiocarboxylate compound and the reaction solvent [gamma]-valerolactone, and reacting to obtain the ester compound. According to the invention, under the promotion action of carbon dioxide, carboxylate or thiocarboxylate is used as an acylation reagent, and amine and alcohol are converted into amide and ester compounds in the absence of a transition metal catalyst, so that acylation reagents such as acyl chloride or anhydride with irritation and corrosivity are avoided; and the method has the advantages of simple operation, mild reaction conditions, high tolerance of substrate functional groups, strong applicability and high yield, and provides an efficient, reliable and economical preparation method for synthesis of amide and ester compounds.

Hypervalent Iodine Reagent-Promoted Hofmann-Type Rearrangement/Carboxylation of Primary Amides

A novel transformation of primary amides to secondary amides promoted by hypervalent iodine reagents was developed. The hypervalent iodine reagent-mediated Hofmann-type rearrangement generated an isocyanate intermediate, which was subsequently trapped by an in situ generated carboxylic acid from the hypervalent iodine reagent to provide the corresponding secondary amides. This method provided a facile and efficient route for the synthesis of secondary amides from primary amides and also revealed novel reactivities of hypervalent iodine reagents.