582325-05-1

Basic information

• Product Name: (R)-3-METHYL-1-[3-(TRIFLUOROMETHYL)PYRIDIN-2-YL]PIPERAZINE
• Synonyms: (R)-3-METHYL-1-[3-(TRIFLUOROMETHYL)PYRIDIN-2-YL]PIPERAZINE
• CAS NO: 582325-05-1
• Molecular Formula: C₁₁H₁₄F₃N₃
• Molecular Weight: 245.24
• Mol File: 582325-05-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-3-METHYL-1-[3-(TRIFLUOROMETHYL)PYRIDIN-2-YL]PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-METHYL-1-[3-(TRIFLUOROMETHYL)PYRIDIN-2-YL]PIPERAZINE(582325-05-1)
• EPA Substance Registry System: (R)-3-METHYL-1-[3-(TRIFLUOROMETHYL)PYRIDIN-2-YL]PIPERAZINE(582325-05-1)

Safety Data

• Hazardous Substances Data: 582325-05-1(Hazardous Substances Data)

Usage

General Description

"(R)-3-Methyl-1-[3-(trifluoromethyl)pyridin-2-yl]piperazine" is a chemical compound that belongs to the piperazine class of compounds. It is a piperazine derivative with a trifluoromethylpyridinyl group and a methyl substitution at the third position of the piperazine ring. (R)-3-METHYL-1-[3-(TRIFLUOROMETHYL)PYRIDIN-2-YL]PIPERAZINE has potential pharmaceutical applications due to its interactions with the central nervous system and serotonin receptors. It is also used in research and development of new drugs for neurological and psychiatric disorders. Additionally, its unique structure and properties make it a valuable tool for studying the structure-activity relationships of piperazine-based compounds.

Upstream product

• 75336-86-6 (2R)-methylpiperazine 
• 65753-47-1 2-chloro-3-trifluoromethyl-pyridine 

Downstream Products

• 683244-36-2 (R)-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)-5-(trifluoromethyl)nicotinaldehyde 
• 683244-29-3 (6-{3-methyl-4-[6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazol-2-yl]-piperazin-1-yl}-5-trifluoromethyl-pyridin-3-yl)-methanol 
• 1065144-78-6 1-Benzenesulfonyl-3-cyclohexyl-4-[(R)-2-methyl-4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carbonyl]-imidazolidin-2-one 
• 1043476-40-9 C₂₁H₂₆F₃N₃O₂S 

Relevant articles and documents

Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1)

High-throughput screening of a small-molecule compound library resulted in the identification of a series of arylsulfonylpiperazines that are potent and selective inhibitors of human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1). Optimization of the initial lead resulted in the discovery of compound (R)-45 (11β-HSD1 IC50 = 3 nM).

4-(2-Pyridyl)piperazine-1-benzimidazoles as potent TRPV1 antagonists

A series of 4-(2-pyridyl)piperazine-1-benzimidazole analogues based on compound 1 was synthesized and evaluated for TRPV1 antagonist activity in capsaicin-induced (CAP) and pH 5.5-induced (pH) FLIPR assays in a human TRPV1-expressing HEK293 cell line. Potent TRPV1 antagonists were identified through SAR studies. From these studies, several antagonists were found, with IC50 values ranging from 32 nM to ～5000 nM. Among these, 11 [IC50 = 90 nM (CAP) and 104 nM (pH)] was further evaluated and found to be orally available in rats (F% = 19.7).