583-58-4 Usage
Description
3,4-Lutidine, also known as 3,4-dimethylpyridine, is an organic compound with the chemical formula C7H9N. It is a colorless to pale yellow liquid with a strong, fishy odor. 3,4-Lutidine is a heterocyclic aromatic amine that is structurally similar to pyridine but with two methyl groups attached to the 3rd and 4th positions. It is a versatile intermediate in the synthesis of various organic compounds and pharmaceuticals.
Uses
Used in Pharmaceutical Industry:
3,4-Lutidine is used as an intermediate in the preparation of active pharmaceutical ingredients (APIs) for the development of various medications. Its unique chemical structure allows it to be a key component in the synthesis of complex organic molecules, which can be further used to create therapeutic agents.
Used in Organic Synthesis:
3,4-Lutidine is used as a reagent and catalyst in various organic synthesis processes. Its ability to form stable complexes with metal ions makes it a valuable component in the synthesis of metal-organic frameworks (MOFs) and other coordination compounds.
Used in Chemical Research:
3,4-Lutidine is utilized in chemical research as a model compound to study the properties and reactions of heterocyclic aromatic amines. Its reactivity and stability make it an ideal candidate for investigating various chemical reactions and mechanisms.
Used in the Preparation of Tetrhydropyridine Derivatives:
3,4-Lutidine is used to prepare tetrhydropyridine derivatives by reduction. These derivatives are important in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. The reduction of 3,4-Lutidine to tetrhydropyridine derivatives allows for the development of new compounds with potential applications in various industries.
Safety Profile
Poison by skin contact.
Moderately toxic by ingestion and
inhalation. When heated to decomposition it
emits toxic fumes of NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 583-58-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,8 and 3 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 583-58:
(5*5)+(4*8)+(3*3)+(2*5)+(1*8)=84
84 % 10 = 4
So 583-58-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H9N/c1-6-3-4-8-5-7(6)2/h3-5H,1-2H3
583-58-4Relevant articles and documents
NOVEL METHODS FOR PREPARATION OF SUBSTITUTED PYRIDINES AND RELATED NOVEL COMPOUNDS
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Paragraph 0195; 0196; 0197; 0220; 0221, (2020/04/10)
The present invention relates to novel methods of preparation of substituted pyridines and the compounds produced therefrom. In particular, the present invention provides efficient methods for the construction of diversely substituted pyridines, with varying substitution patterns under simple and metal-free conditions with high atom- and pot-economy and excellent functional group tolerance, and which are useful for the synthesis of natural products.
A simple, tandem approach to the construction of pyridine derivatives under metal-free conditions: A one-step synthesis of the monoterpene natural product, (-)-actinidine
Uredi, Dilipkumar,Motati, Damoder Reddy,Blake Watkins
supporting information, p. 3270 - 3273 (2019/03/30)
A simple and modular one-step synthesis of diversely substituted pyridines from readily available α,β-unsaturated carbonyl compounds and propargylic amines has been developed. The present protocol has a broad substrate scope and allows access to multi-substituted pyridines with select control of the substitution pattern under mild and metal-free conditions. The reaction involves imine formation followed by concomitant cyclization through an allenyl intermediate to afford pyridines in excellent yields, with water as the sole by-product. This mild strategy is also suitable for functionalization of natural products or other advanced intermediates having α,β-unsaturated carbonyl functionality. The utility of the present protocol was showcased with the synthesis of the monoterpene alkaloid, (-)-actinidine, an ant-associated iridoid.
Synthesis of two potential heterocyclic amine food mutagens
Tanga, Mary J.,Kozocas, Joseph A.,Tochimoto, Todd K.
, p. 661 - 665 (2008/09/21)
(Chemical Equation Presented) The syntheses of two potential food mutagens formed during cooking, 2-amino-3,6,7-trimethyl-3H-imidazo[4,5-b]pyridine (1) and 2-amino-3,6,7-trimethyl-3H-imidazo[4,5-c]pyridine (2), are described.