5830-31-9

Basic information

• Product Name: N,N-dimethylhydrocinnamide
• Synonyms: N,N-dimethylhydrocinnamide;N,N-Dimethyl-3-phenylpropionamide;N,N-Dimethylbenzenepropanamide;N,N-Dimethylbenzenepropionamide
• CAS NO: 5830-31-9
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 5830-31-9.mol
• Article Data: 50

Chemical Properties

• Melting Point: 62-63 °C
• Boiling Point: 294.7°Cat760mmHg
• Flash Point: 129.4°C
• Appearance: /
• Density: 1.006g/cm³
• Vapor Pressure: 0.00159mmHg at 25°C
• Refractive Index: 1.518
• PKA: -0.50±0.70(Predicted)
• CAS DataBase Reference: N,N-dimethylhydrocinnamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethylhydrocinnamide(5830-31-9)
• EPA Substance Registry System: N,N-dimethylhydrocinnamide(5830-31-9)

Safety Data

• Hazardous Substances Data: 5830-31-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H15NO/c1-12(2)11(13)9-8-10-6-4-3-5-7-10/h3-7H,8-9H2,1-2H3

Upstream product

• 20929-37-7 N,N-Dimethyl-benzylmalonamidsaeureaethylester 
• 127-19-5 N,N-dimethyl acetamide 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 124-40-3 dimethyl amine 
• 645-45-4 hydrocinnamic acid chloride 
• 22191-61-3 N,N-dimethyl-3-phenylthiopropionamide 
• 17431-39-9 (E)-N,N-dimethylcinnamamide 
• 5631-70-9 4',5,7-trimethoxyflavone 
• 2021-28-5 ethyl dihydrocinnamate 
• 68-12-2 N,N-dimethyl-formamide 
• 501-52-0 3-Phenylpropionic acid 
• 58131-63-8 <(N,N-dimethylcarbamoyl)methylene>triphenylphosphorane 
• 100-51-6 benzyl alcohol 

Downstream Products

• 16487-48-2 3-Phenyl-propenyliden-bis-(dimethylamin), 1,1-Bis--3-phenyl-propen-(1') 
• 104-53-0 3-phenyl-propionaldehyde 
• 122-97-4 3-Phenyl-1-propanol 
• 29372-37-0 1-deutero-3-phenylpropionaldehyde 
• 940-43-2 N-methyl-3-phenylpropanamide 
• 61930-93-6 5-Phenyl-2-(phenylmethyl)-l-pentene 
• 61930-91-4 ((E)-2-Benzyl-5-phenyl-pent-2-enyl)-dimethyl-amine 
• 88431-04-3 N,N-dimethyl-2-benzylpent-4-enamide 
• 2021-28-5 ethyl dihydrocinnamate 
• 101781-09-3 N,N-dimethyl-1,4-diphenylbut-2-ylamine 
• 56583-95-0 1-(dimethyl(phenyl)silyl)ethanone 
• 2550-26-7 4-Phenyl-2-butanone 
• 103-05-9 4-phenyl-2-methyl-2-butanol 
• 22191-61-3 N,N-dimethyl-3-phenylthiopropionamide 

Relevant articles and documents

Direct amidation of acid fluorides using germanium amides

Amide functional groups are an essential linkage that are found in peptides, proteins, and pharmaceuticals and new methods are constantly being sought for their formation. Here, a new method for their preparation is presented where germanium amides Ph3GeNR2convert acid fluorides directly to amides. These germanium amides serve to abstract the fluorine atom of the acid fluoride and transfer their amide group -NR2to the carbonyl carbon, and so function as amidation reagents.

Catalytic α-Hydroarylation of Acrylates and Acrylamides via an Interrupted Hydrodehalogenation Reaction

The palladium-catalyzed, α-selective hydroarylation of acrylates and acrylamides is reported. Under optimized conditions, this method is highly tolerant of a wide range of substrates including those with base sensitive functional groups and/or multiple enolizable carbonyl groups. A detailed mechanistic study was undertaken, and the high selectivity of this transformation was shown to be enabled by the formation of a [PdII(Ar)(H)] intermediate, which performs selective hydride insertion into the β-position of α,β-unsaturated carbonyl compounds.

method for alpha-alkylation of acetamides and thioacetamides under catalysis of nickel

The invention discloses a method for alpha-alkylation of acetamide and thioacetamide under the catalysis of nickel. The method comprises the following steps: by taking a complex generated in situ by adivalent nickel salt and a phosphine ligand as a catalyst and primary alcohol as an alkylation reagent, performing alpha-alkylation reaction on acetamide or thioacetamide in an alkaline environment to prepare amide or thioamide. According to the alpha-alkylation reaction of acetamide and thioacetamide, the active catalyst can be generated in situ from a bivalent nickel salt and a phosphine ligand, so that the catalyst is prevented from being prepared in advance, the operation is simple and convenient, and experimental steps and cost are saved.