58310-28-4Relevant articles and documents
Carbenoid reactions of trifluoromethylelement compounds. Part 6. Syntheses and characterization of difluoromethylphosphonium, arsonium and stibonium compounds from reactions of triorganopnicogens with Zn(CF3)Br·2D and Bi(CF3)3
Kirij,Pasenok,Yagupolskii, Yu.L.,Fitzner,Tyrra,Naumann
, p. 207 - 212 (1999)
(Difluoromethyl)triorganopnicogenium tetrachlorobismuthates are isolated in moderate to very good yields from the reactions of several R3E derivatives(E=P, As) with the reagent Bi(CF3)3/AlCl3. (Difluoromethyl)tr
Photoredox-Catalyzed Bromodifluoromethylation of Alkenes with (Difluoromethyl)triphenylphosphonium Bromide
Lin, Qing-Yu,Ran, Yang,Xu, Xiu-Hua,Qing, Feng-Ling
, p. 2419 - 2422 (2016)
Under visible-light photoredox conditions, difluoromethyltriphenylphosphonium bromide was used as the precursor of the CF2H radical for bromodifluoromethylation of alkenes. The presence of catalytic CuBr2 resulted in the selective fo
Visible-Light-Induced Radical Difluoromethylation/Cyclization of Unactivated Alkenes: Access to CF2H-Substituted Quinazolinones
Chen, Xiaoyu,Liu, Bo,Pei, Congcong,Li, Jingya,Zou, Dapeng,Wu, Yangjie,Wu, Yusheng
supporting information, p. 7787 - 7791 (2021/10/20)
A mild and efficient visible-light-induced radical difluoromethylation/cyclization of unactivated alkenes toward the synthesis of substituted quinazolinones with easily accessible difluoromethyltriphenylphosphonium bromide has been developed. The transformation has the advantages of wide functional group compatibility, a broad substrate scope, and operational simplicity. The benign protocol offers a facile access to pharmaceutically valuable difluoromethylated polycyclic quinazolinones.
Direct Nucleophilic Difluoromethylation of Carbonyl Compounds
Deng, Zuyong,Lin, Jin-Hong,Cai, Ji,Xiao, Ji-Chang
supporting information, p. 3206 - 3209 (2016/07/14)
Phosphonium salt ([Ph3P+CF2H] Br-, DFPB) was found to be an efficient nucleophilic difluoromethylation reagent. Although DFPB is known as a phosphonium ylide precursor, its reaction with carbonyl compounds under traditional Wittig reaction conditions did not give the expected Wittig difluoroolefinated products, but afforded the nucleophilic difluoromethylation products, α-CF2H alcohols. Mechanistic investigation reveals that the unexpected transformation proceeded via the direct transfer of the CF2H group, which resulted from the high P-O affinity.