58366-64-6

Basic information

• Product Name: 5-METHYLCYTOSINE HYDROCHLORIDE
• Synonyms: Cytosine, 5-methyl- (VAN) (8CI);4-AMINO-2-HYDROXY-5-METHYLPYRIMIDINE;4-AMINO-2-HYDROXY-5-METHYLPYRIMIDINE HYDROCHLORIDE;5-METHYLCYTOSINE HYDROCHLORIDE;4-amino-5-methyl-1H-pyrimidin-2-one hydrochloride;5-METHYLCYTOSINE HCL;5-METHYLCYTOSINE HYDROCHLORIDE 98%;5-Methylcytosine hydrochloride ,98%
• CAS NO: 58366-64-6
• Molecular Formula: C5H8ClN3O
• Molecular Weight: 161.59
• EINECS: 261-223-9
• Product Categories: Nucleotides and Nucleosides;Pyrimidines;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Nucleic acids;Bases & Related Reagents;Nucleotides;Amines
• Mol File: 58366-64-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 293-295°C effervescence
• Boiling Point: 285 °C at 760 mmHg
• Flash Point: 126.1 °C
• Appearance: Crystalline
• Storage Temp.: Store at RT.
• Solubility: DMSO (Heated), Methanol (Slightly)
• Stability: This compound looses chloride readily. Keep container tightly closed, and store in freezer.
• CAS DataBase Reference: 5-METHYLCYTOSINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYLCYTOSINE HYDROCHLORIDE(58366-64-6)
• EPA Substance Registry System: 5-METHYLCYTOSINE HYDROCHLORIDE(58366-64-6)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 58366-64-6(Hazardous Substances Data)

Usage

Description

5-Methylcytosine hydrochloride is a derivative of dibarbituric acid, which is a crystalline compound. It plays a significant role in various applications due to its unique chemical properties.

Uses

Used in Chemical Analysis:
5-Methylcytosine hydrochloride is used as a standard in high-performance liquid chromatography (HPLC) for the estimation of global methylation rates. This application is crucial in understanding the epigenetic modifications that occur in various biological processes.
Used in Mass Spectroscopic Analysis:
In high-resolution mass spectroscopic analysis, 5-Methylcytosine hydrochloride is utilized to study the methylation patterns in DNA and RNA molecules. This helps in identifying and characterizing the epigenetic changes that are associated with various diseases and conditions.
Used in Pharmaceutical Industry:
As a derivative of dibarbituric acid, 5-Methylcytosine hydrochloride has potential applications in the pharmaceutical industry for the development of drugs targeting epigenetic modifications. These modifications are known to play a role in the regulation of gene expression and are implicated in various diseases, including cancer.
Used in Research and Development:
5-Methylcytosine hydrochloride is also used in research and development for studying the role of DNA methylation in gene regulation, cellular differentiation, and disease progression. This knowledge can contribute to the development of novel therapeutic strategies and diagnostic tools.

Biochem/physiol Actions

5-Methylcytosine mediates gene expression, genomic imprinting and inhibition of transposable elements. It is closely associated with translational fidelity and tRNA recognition.

InChI:InChI=1/C5H7N3O.ClH/c1-3-2-7-5(9)8-4(3)6;/h2H,1H3,(H3,6,7,8,9);1H