58396-29-5

Basic information

• Product Name: (R)-1-cyclohexylethyl acetate
• Synonyms: (R)-1-cyclohexylethyl acetate
• CAS NO: 58396-29-5
• Molecular Weight: 170.252
• Mol File: 58396-29-5.mol
• Article Data: 33

Chemical Properties

• CAS DataBase Reference: (R)-1-cyclohexylethyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-cyclohexylethyl acetate(58396-29-5)
• EPA Substance Registry System: (R)-1-cyclohexylethyl acetate(58396-29-5)

Safety Data

• Hazardous Substances Data: 58396-29-5(Hazardous Substances Data)

Upstream product

• 876-27-7 4-chlorophenyl acetate 
• 823-76-7 Cyclohexyl methyl ketone 
• 108-22-5 Isopropenyl acetate 
• 1193-81-3 rac-1-cyclohexylethanol 
• 2043-61-0 cyclohexanecarbaldehyde 
• 931-48-6 2-cyclohexylacetylene 
• 64-19-7 acetic acid 
• 3113-98-2 (S)-(+)-1-cyclohexylethanol 
• 3113-99-3 (R)-1-cyclohexylethanol 
• 104-15-4 toluene-4-sulfonic acid 
• 108-24-7 acetic anhydride 
• 108-05-4 vinyl acetate 
• 13487-27-9 1-cyclohexylethan-1-yl acetate 
• 141-78-6 ethyl acetate 

Downstream Products

• 3113-99-3 (R)-1-cyclohexylethanol 

Relevant articles and documents

Asymmetric Chemoenzymatic Reductive Acylation of Ketones by a Combined Iron-Catalyzed Hydrogenation–Racemization and Enzymatic Resolution Cascade

A general and practical process for the conversion of prochiral ketones into the corresponding chiral acetates has been realized. An iron carbonyl complex is reported to catalyze the hydrogenation–dehydrogenation–hydrogenation of prochiral ketones. By merging the iron-catalyzed redox reactions with enantioselective enzymatic acylations a wide range of benzylic, aliphatic and (hetero)aromatic ketones, as well as diketones, were reductively acylated. The corresponding products were isolated with high yields and enantioselectivities. The use of an iron catalyst together with molecular hydrogen as the hydrogen donor and readily available ethyl acetate as acyl donor make this cascade process highly interesting in terms of both economic value and environmental credentials.

Catalytic enantioselective addition of methyltriisopropoxititanium to aldehydes

An efficient catalyst for the enantioselective synthesis of chiral methyl carbinols from aldehydes is presented. The system uses methyltriisopropoxytitanium as a nucleophile and a readily available binaphthyl derivative as a chiral ligand. The enantioselective methylation of both aromatic and aliphatic aldehydes proceeds with good yields and high enantioselectivities under mild conditions.

Iridium-Catalyzed Asymmetric Hydrogenation with Simple Cyclohexane-Based P/S Ligands: In Situ HP-NMR and DFT Calculations for the Characterization of Reaction Intermediates

We report a reduced but structurally valuable phosphite/phosphinite-thioether ligand library for the Ir-hydrogenation of 40 minimally functionalized alkenes, including relevant examples with poorly coordinative groups. We found that enantiomeric excesses are mainly dependent on the substrate structure and on some ligand parameters (i.e., the type of thioether/phosphorus moieties and the configuration of the phosphite group), whereas the substituents of the biaryl phosphite moiety had little impact. By tuning the ligand parameters we were able to find highly selective catalysts for a range of substrates (ees up to 99%). These phosphite/phosphinite-thioether ligands have a simple backbone and thus yield simple NMR spectra that reduce signal overlap and facilitate the identification of relevant intermediates. Therefore, by combining HP-NMR spectroscopy and theoretical studies, we were also able to identify the catalytically competent Ir-dihydride alkene species, which made it possible to explain the enantioselectivity obtained.