5843-49-2

Basic information

• Product Name: Benzoyl isocyanate, 3-nitro-
• CAS NO: 5843-49-2
• Molecular Formula: C8H4N2O4
• Molecular Weight: 192.131
• Mol File: 5843-49-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzoyl isocyanate, 3-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl isocyanate, 3-nitro-(5843-49-2)
• EPA Substance Registry System: Benzoyl isocyanate, 3-nitro-(5843-49-2)

Safety Data

• Hazardous Substances Data: 5843-49-2(Hazardous Substances Data)

Upstream product

• 79-37-8 oxalyl dichloride 
• 645-09-0 3-nitrobenzamide 
• 121-92-6 3-nitrobenzoic acid 
• 121-90-4 m-nitrobenzoic acid chloride 
• 917-61-3 sodium isocyanate 

Downstream Products

• 72897-41-7 3-isopropyl-2-isopropylimino-6-(3-nitro-phenyl)-2,3-dihydro-[1,3,5]oxadiazin-4-one 
• 132981-01-2 1-(3-Nitro-benzoyl)-3-[(S)-3-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-urea 
• 138193-70-1 1-[4-(5-Chloro-pyrimidin-2-yloxy)-3-trifluoromethyl-phenyl]-3-(3-nitro-benzoyl)-urea 
• 61831-88-7 methyl-3 nitro-3' phenyl-6 dihydro-3,4 dioxo-2,4 2H-oxadiazine-1,3,5 
• 1235975-80-0 C₁₅H₁₉N₃O₆ 
• 1130403-96-1 C₁₅H₁₁N₃O₆ 
• 1130403-97-2 C₁₃H₁₀N₄O₄ 
• 66913-70-0 1-(N-3-nitrobenzoyl-carbamoyl)-2-cyanoaziridine 
• 120982-38-9 N-(3-nitro-benzoyl)-N'-phenyl-urea 

Relevant articles and documents

Convenient One-Pot Two-Step Synthesis of Symmetrical and Unsymmetrical Diacyl Ureas, Acyl Urea/Carbamate/Thiocarbamate Derivatives, and Related Compounds

A wide range of chemicals such as amides, hydrazides, amines, alcohols, carbazate, and sulfonate were reacted with acyl isocyanates generated by the reaction of primary amides with oxalyl chloride to give symmetrical and unsymmetrical diacyl urea derivatives, acyl ureas/carbamates/thiocarbamates, and related compounds. This method provides means for convenient one-pot, two-step synthesis of compounds bearing urea, carbamate, and other functional groups from cheap and commercially available starting reagents. It is expected that the results presented in this report will expand the medicinal chemist’s toolbox.

Synthesis and antitumor activity of novel N-benzoyl-N'-substituted pyrimidinyl (thio)semicarbazide derivatives

A series of substituted pyrimidinyl (thio)semicarbazide derivatives were designed and synthesized. The antitumor results showed that the activity of thiosemicarbazide compounds (series II) was generally higher than that of the corresponding semicarbazide derivatives (series I). Among them, IIk displayed higher cytotoxicity against HL-60, BGC-823 and Bel-7402 than that of adriamycin and exhibited broad in vitro cytotoxicity against 13 human tumor cell lines. Meanwhile, the cytotoxic selectivity and anti-multidrug resistance were evaluated, and IIk exhibited selective cytotoxicity against cancer cells in comparison to human normal cells and had significant anti-multidrug resistance capability. The bioassay results showed that IIk showed great promise as a potent lead compound for further antitumor discovery.

Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents

3-Haloacylamino benzoylureas (3-HBUs) consist of a new family of tubulin ligands that kill cancer cells through mitotic arrest. In exploring the structure-activity relationship (SAR), 17 analogues defined through variations of formylurea at the 1-position