58483-94-6

Basic information

• Product Name: 3-Amino-2-chloropyridine-4-carboxylic acid
• Synonyms: 3-Amino-2-chloropyridine-4-carboxylic acid;3-aMino-2-chloroisonicotinic acid
• CAS NO: 58483-94-6
• Molecular Formula: C₆H₅ClN₂O₂
• Molecular Weight: 172.5691
• Mol File: 58483-94-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 478.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.577±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.74±0.10(Predicted)
• CAS DataBase Reference: 3-Amino-2-chloropyridine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-2-chloropyridine-4-carboxylic acid(58483-94-6)
• EPA Substance Registry System: 3-Amino-2-chloropyridine-4-carboxylic acid(58483-94-6)

Safety Data

• Hazardous Substances Data: 58483-94-6(Hazardous Substances Data)

Usage

Uses

2-Chloro-3-aminoisonicotinic Acid is a useful synthetic intermediate.

Upstream product

• 6298-19-7 2-chloro-3-aminopyridine 
• 1312105-89-7 3-((tert-butoxycarbonyl)amino)-2-chloroisonicotinic acid 
• 209798-48-1 tert-butyl N-(2-chloro-3-pyridinyl)carbamate 
• 173435-41-1 methyl 3-amino-2-chloropyridine-4-carboxylate 

Downstream Products

• 39217-08-8 2-chloropyridine-3,4-diamine 
• 1260663-37-3 4,8-dichloropyrido[3,4-d]pyrimidine 
• 84341-13-9 8-chloro-3H-pyrido [3 ,4-d]pyrimidin-4-one 

Relevant articles and documents

Method for preparing aldehyde and acid by electrochemical dehydrochlorination of polychloromethylpyridine derivatives

The invention discloses a method for preparing aldehyde and an acid by electrochemical dechlorination of a polychloromethylpyridine derivative, the method comprises the following steps: dissolving thepolychloromethylpyridine derivative in an acetic acid and acetate- containing buffer solution to obtain an electrolytic reaction solution; taking the electrolytic reaction solution as a cathode liquid, performing electrolytic reduction dechlorination reaction at a cathode, and hydrolyzing in the solution to obtain a polychlorinated pyridylaldehyde or acid derivative. The polychloromethylpyridinederivative is shown in formula (I), and the product polychlorinated pyridylaldehyde or acid derivative is shown in formula (II): in the formula (I), m is 0, 1, 2, 3 or 4, n is 0 or 1, and R' is an easy-to-oxidize or easy-to-hydrolyze substituent. The m and the R' in the formula (II) are same as that in the formula (I), R is H or OH, no waste acid is generated in the preparation process, the easy-to-oxidize or easy-to-hydrolyze substituent contained in the polychloromethylpyridine derivative and carbon-chlorine bonds on pyridine rings are not affected, and the recovery conversion rate is high.

BICYCLIC ETHER O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITORS

Described herein are compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables Ar, X, R1, R3, R 4, Y1, Y2, n and p are as defined herein.

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Histone lysine demethylases (KDMs) are involved in the dynamic regulation of gene expression and they play a critical role in several biological processes. Achieving selectivity over the different KDMs has been a major challenge for KDM inhibitor development. Here we report potent and selective KDM5 covalent inhibitors designed to target cysteine residues only present in the KDM5 sub-family. The covalent binding to the targeted proteins was confirmed by MS and time-dependent inhibition. Additional competition assays show that compounds were non 2-OG competitive. Target engagement and ChIP-seq analysis showed that the compounds inhibited the KDM5 members in cells at nano- to micromolar levels and induce a global increase of the H3K4me3 mark at transcriptional start sites.