585-45-5

Basic information

• Product Name: 2-{[3-(trifluoromethyl)phenoxy]methyl}oxirane
• CAS NO: 585-45-5
• Molecular Formula: C₁₀H₉F₃O₂
• Molecular Weight: 218.1725
• Mol File: 585-45-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 246.9°C at 760 mmHg
• Flash Point: 110.2°C
• Density: 1.304g/cm³
• Vapor Pressure: 0.0416mmHg at 25°C
• Refractive Index: 1.471
• CAS DataBase Reference: 2-{[3-(trifluoromethyl)phenoxy]methyl}oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[3-(trifluoromethyl)phenoxy]methyl}oxirane(585-45-5)
• EPA Substance Registry System: 2-{[3-(trifluoromethyl)phenoxy]methyl}oxirane(585-45-5)

Safety Data

• Hazardous Substances Data: 585-45-5(Hazardous Substances Data)

Usage

Chemical compound

Epoxide with a trifluoromethyl group and a phenoxy group attached to the oxirane ring

Also known as

Trifenagrel and CVN162

Potential therapeutic effects

Treatment of thrombosis and other cardiovascular conditions

Mechanism of action

Potent and selective antagonist of the platelet P2Y12 receptor

Role in platelet aggregation

Inhibits blood clot formation

Potential application

Development of antithrombotic drugs

Research status

Further evaluation needed for efficacy and safety in clinical use

Upstream product

• 98-17-9 3-Trifluoromethylphenol 
• 106-89-8 epichlorohydrin 
• 3132-64-7 1,2-Epoxy-3-bromopropane 

Downstream Products

• 5214-61-9 1-(Methyl-benzylamino)-3-(3-trifluormethyl-phenoxy)-propanol-⁽²⁾ 
• 5002-97-1 N-Methyl-2-hydroxy-3-(m-trifluormethylphenoxy)-propylamin 
• 1224936-53-1 C₁₆H₂₂F₃NO₃ 
• 1224936-56-4 C₁₉H₂₀F₃NO₂ 
• 54094-19-8 dimethyl [3-(3-(trifluoromethyl)phenoxy)-2-oxopropyl]phosphonate 

Relevant articles and documents

Substituted diaryl compound and preparation method and application thereof

The invention relates to the field of medicinal chemistry, in particular to a substituted diaryl compound (I). The preparation method comprises the following steps: medicine preparation and medical application thereof. Test results show that the substituted diaryl compound has a good inhibition effect on human lung cancer (A549), human ovarian cancer (SKOV3), human melanoma (A375) and human colon cancer (LOVO) cells. Formula (I):

Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors

A novel class of NaV1.7 inhibitors has been identified by high-throughput screening followed by structure activity relationship studies. Among this series of compounds, piperidine 9o showed potent human and mouse NaV1.7 inhibitory activities with fair subtype selectivity over NaV1.5. Compound 9o successfully demonstrated analgesic efficacy in mice comparable to that of the currently used drug, mexiletine, but with an expanded central nervous system safety margin.

ANALGESIC THAT BINDS FILAMIN A

A compound, composition and method are disclosed that can provide analgesia. A contemplated compound has a structure that corresponds to Formula A, wherein A, B, X, R1, R2, R7 and R8, and the dashed lines are defined within.