58509-73-2Relevant articles and documents
Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2
De Savi, Chris,Morley, Andrew D.,Nash, Ian,Karoutchi, Galith,Page, Ken,Ting, Attilla,Gerhardt, Stefan
, p. 271 - 277 (2012)
Directed screening has identified a novel series of non-zinc binding MMP13 inhibitors that possess good levels of activity whilst demonstrating excellent selectivity over related MMPs. A lead optimisation campaign has delivered compounds with enhanced MMP