5852-92-6

Basic information

• Product Name: 1,2-DIMETHYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
• Synonyms: 1,2-DIMETHYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE;CARNEGINE HCL;CARNEGINE HYDROCHLORIDE;1,2-Dimethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolineHCl;3-(4-CHLOROPHENYL)IMINO-1-(1-PIPERIDYLMETHYL)INDOL-2-ONE;1,2-DIMETHYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 98%;1,2-Dimethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride,98%
• CAS NO: 5852-92-6
• Molecular Formula: C13H20ClNO2
• Molecular Weight: 257.76
• Mol File: 5852-92-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 210-215 °C
• Boiling Point: 302 °C at 760 mmHg
• Flash Point: 100.9 °C
• Appearance: /
• Vapor Pressure: 0.00102mmHg at 25°C
• CAS DataBase Reference: 1,2-DIMETHYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIMETHYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE(5852-92-6)
• EPA Substance Registry System: 1,2-DIMETHYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE(5852-92-6)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 45-36/37/39-26
• HazardClass: IRRITANT
• Hazardous Substances Data: 5852-92-6(Hazardous Substances Data)

Usage

General Description

1,2-Dimethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is a chemical compound that belongs to the class of isoquinoline alkaloids. It is a derivative of tetrahydroisoquinoline and contains two methyl and two methoxy groups. 1,2-DIMETHYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE is commonly used in research and pharmaceutical applications, particularly in the study of neurotransmitters and central nervous system function. It has exhibited potential as a therapeutic agent for various neurological disorders and has been studied for its anticonvulsant and analgesic properties. The hydrochloride salt form is commonly used for research and experimental purposes due to its stability and solubility in water.

InChI:InChI=1/C13H19NO2/c1-9-11-8-13(16-4)12(15-3)7-10(11)5-6-14(9)2/h7-9H,5-6H2,1-4H3/p+1/t9-/m1/s1

Upstream product

• 4721-98-6 6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline 
• 17104-28-8 1-methyl-6,7-dimethoxy-2-methyl-3,4-dihydro-isoquinolinium iodide 

Relevant articles and documents

Potential cancer chemopreventive activity of simple isoquinolines, 1-benzylisoquinolines, and protoberberines

Seventeen simple isoquinolines, 15 1-benzylisoquinolines, and 19 protoberberines were tested for their inhibitory activities against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol- 13-acetate (TPA) in Raji cells. Among the tested alkaloids, the inhibitory activity of all 1-benzylisoquinolines and 11 protoberberines was higher than that of β-carotene. The 1-benzylisoquinolines 19, 21, 22, 29, and 34 and protoberberines 41, 47-49, 51, 52, and 55 showed potent inhibitory effects on EBV-EA induction (96-100% inhibition at 1 × 103 mol ratio/TPA). These alkaloids were more active than the naturally occurring alkaloids, 23, 25, 33, 53, and 54. In addition, fifteen simple isoquinolines, eighteen 1-benzylisoquinolines and eight protoberberines were evaluated with respect to their ability to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals. Nine simple isoquinolines, ten 1-benzylisoquinolines, and four protoberberines were more potent than α-tocopherol, and four 1-benzylisoquinolines, 20 and 28-30, exhibited potent activities (SC50 4.5-5.8 μM). Their activities were higher than the naturally occurring alkaloids, 23, 25, and 33. Therefore, some of the isoquinoline alkaloids indicating the high activity on both assays may be potentially valuable cancer chemopreventive agents. Structure-activity relationships are discussed for both tests.