58546-54-6 Usage
Description
Gomisin A is a lignan compound that has been isolated from the plant Schisandra chinensis. It is known for its various biological activities and potential health benefits.
Uses
Used in Pharmaceutical Industry:
Gomisin A is used as a hepatoprotective agent for its ability to increase the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism. This helps in protecting against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis.
Used in Cardiovascular Applications:
Gomisin A is used as a protective agent for its potent protective effects on ET-1-induced dysfunctional human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), which can be beneficial in treating cardiovascular diseases.
Used in Cholestasis Treatment:
Gomisin A is used as an anti-cholestasis agent, as it decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen.
Chemical Properties:
Gomisin A is a white powder in its chemical form.
Check Digit Verification of cas no
The CAS Registry Mumber 58546-54-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,5,4 and 6 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 58546-54:
(7*5)+(6*8)+(5*5)+(4*4)+(3*6)+(2*5)+(1*4)=156
156 % 10 = 6
So 58546-54-6 is a valid CAS Registry Number.
InChI:InChI=1/C23H28O7/c1-12-7-13-8-16-20(30-11-29-16)22(28-6)17(13)18-14(10-23(12,2)24)9-15(25-3)19(26-4)21(18)27-5/h8-9,12,24H,7,10-11H2,1-6H3/t12-,23-/m0/s1
58546-54-6Relevant articles and documents
Transformation of schizandrin into gomisin A by use of microbial O-demethylation and chemical reactions
Kanatani,Sakakibara,Tanaka,Niitsu,Ikeya,Wakamatsu,Maruno
, p. 1054 - 1057 (2007/10/02)
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Synthesis of optically pure gomisin A and schizandrin: The first total synthesis of gomisin A and schizandrin having naturally occurring configurations
Tanaka,Mukaiyama,Mitsuhashi,Wakamatsu
, p. 4165 - 4168 (2007/10/02)
The total synthesis of gomisin A and schizandrin having natural configurations were accomplished for the first time. The key feature of these syntheses is a highly efficient intramolecular oxidative coupling of the intermediates 9 and 21, which can be obtained as both enantiomers in optically pure forms. The manipulation of the lactone moieties of 7 and 22 afforded natural enantiomers of schizandrin and gomisin A.