586-22-1

Basic information

• Product Name: 3-fluoro-4-methoxypropiophenone
• Synonyms: 1-(3-fluoro-4-methoxyphenyl)propan-1-one;1-Propanone, 1-(3-fluoro-4-Methoxyphenyl)-;1-(3-Fluoro-4-methoxyphenyl)propan-1-one, 2-Fluoro-4-propanoylanisole;1-(3-Fluoro-4-methoxyphenyl)
• CAS NO: 586-22-1
• Molecular Formula: C₁₀H₁₁FO₂
• Molecular Weight: 182.2
• Product Categories: Adehydes, Acetals & Ketones;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds
• Mol File: 586-22-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 83-85 °C
• Boiling Point: 278.5°Cat760mmHg
• Flash Point: 118.5°C
• Appearance: /
• Density: 1.099g/cm³
• Vapor Pressure: 0.00425mmHg at 25°C
• Refractive Index: 1.486
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-fluoro-4-methoxypropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-4-methoxypropiophenone(586-22-1)
• EPA Substance Registry System: 3-fluoro-4-methoxypropiophenone(586-22-1)

Safety Data

• Hazardous Substances Data: 586-22-1(Hazardous Substances Data)

Usage

Preparation

Obtained by reaction of propionyl chloride or propionic anhydride with 2-fluoroanisole in the presence of aluminium chloride in carbon disulfide.

InChI:InChI=1/C10H11FO2/c1-3-9(12)7-4-5-10(13-2)8(11)6-7/h4-6H,3H2,1-2H3

Upstream product

• 321-28-8 1-fluoro-2-methoxybenzene 
• 79-03-8 propionyl chloride 
• 123-62-6 propionic acid anhydride 
• 351-54-2 3-fluoro-p-anisaldehyde 
• 925-90-6 ethylmagnesium bromide 
• 1649-96-3 1-(3-fluoro-4-methoxyphenyl)propan-1-ol 
• 331-62-4 3-fluoro-4-methoxybenzonitrile 
• 2357-52-0 3-fluoro-4-methoxyphenyl bromide 
• 455-91-4 1-(3-fluoro-4-methoxyphenyl)ethanone 

Downstream Products

• 586-16-3 1-(3-fluoro-4-hydroxyphenyl)propan-1-one 
• 441-33-8 2-(3-fluoro-4-methoxy-phenyl)-3-methyl-quinoline-4-carboxylic acid 
• 577-74-2 6-chloro-2-(3-fluoro-4-methoxy-phenyl)-3-methyl-quinoline-4-carboxylic acid 
• 445-84-1 6-bromo-2-(3-fluoro-4-methoxy-phenyl)-3-methyl-quinoline-4-carboxylic acid 
• 442-11-5 2-(3-fluoro-4-methoxy-phenyl)-3-methyl-indole 
• 85720-35-0 cis-3,4-bis(3-fluoro-4-methoxyphenyl)hex-3-ene 
• 4394-62-1 α-Hydroxyimino-3-fluor-4-methoxy-propiophenon 
• 970-03-6 meso-3,4-bis(3-fluoro-4-hydroxyphenyl)hexane 
• 2249-64-1 meso-3,3'-difluorohexestrol dimethyl ether 
• 394-07-0 6-bromo-2-(3-fluoro-4-methoxy-phenyl)-3-methyl-quinoline 
• 4394-65-4 α-Amino-3-fluor-4-methoxy-propiophenon 
• 1010800-91-5 methyl 3-(3-fluoro-4-methoxyphenyl)-2-methyl-3-oxopropanoate 
• 1010800-75-5 4-(3-fluoro-4-methoxyphenyl)-3-methyl-4-oxobutanoic acid methyl ester 
• 1094101-93-5 4-(3-Fluoro-4-methoxyphenyl)-3-methyl-4-oxobutanoic acid 

Relevant articles and documents

DMF Dimethyl Acetal as Carbon Source for α-Methylation of Ketones: A Hydrogenation-Hydrogenolysis Strategy of Enaminones

A novel heterogeneous catalytic hydrogenation-hydrogenolysis strategy has been developed for the α-methylation of ketones via enaminones using DMF dimethyl acetal as carbon source. This strategy provides a very convenient route to α-methylated ketones using a variety of ketones without any base or oxidant. (Chemical Equation Presented).

Phosphodiesterase inhibitors. Part 5: Hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration

(-)-6-(7-Methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl) -5-methyl-4,5-dihydropyridazin-3(2H)-one (KCA-1490) exhibits moderate dual PDE3/4-inhibitory activity and promises as a combined bronchodilatory/anti- inflammatory agent. N-alkylation of the pyridazinone ring markedly enhances potency against PDE4 but suppresses PDE3 inhibition. Addition of a 6-aryl-4,5-dihydropyridazin-3(2H)-one extension to the N-alkyl group facilitates both enhancement of PDE4-inhibitory activity and restoration of potent PDE3 inhibition. Both dihydropyridazinone rings, in the core and extension, can be replaced by achiral 4,4-dimethylpyrazolone subunits and the core pyrazolopyridine by isosteric bicyclic heteroaromatics. In combination, these modifications afford potent dual PDE3/4 inhibitors that suppress histamine-induced bronchoconstriction in vivo and exhibit promising anti-inflammatory activity via intratracheal administration.

PYRIDAZINONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT

It is to provide a novel pyridazinone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: wherein R1 represents H or C1-6 alkyl, each of R2 and R3 represents H, X, C1-6 alkoxy, Z represents O or S, and A represents AA or BB, wherein AA represents: and BB represents: wherein R4 represents H or C1-6 alkyl, and each of R5 and R6 represents C1-6 alkyl.