586-36-7

Basic information

• Product Name: Benzenediazonium, 3-nitro-, tetrafluoroborate(1-)
• CAS NO: 586-36-7
• Molecular Formula: C6H4N3O2.BF4
• Molecular Weight: 236.921
• Mol File: 586-36-7.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Benzenediazonium, 3-nitro-, tetrafluoroborate(1-)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenediazonium, 3-nitro-, tetrafluoroborate(1-)(586-36-7)
• EPA Substance Registry System: Benzenediazonium, 3-nitro-, tetrafluoroborate(1-)(586-36-7)

Safety Data

• Hazardous Substances Data: 586-36-7(Hazardous Substances Data)

Upstream product

• 99-09-2 3-nitro-aniline 
• 13755-29-8 sodium tetrafluoroborate 
• 462-34-0 boron trifluoride-tetrahydrofuran complex 

Downstream Products

• 1469-74-5 3,4'-dinitrobenzophenone 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 87014-29-7 1-nitro-3-(2,2,2-trifluoroethoxy)benzene 
• 4103-30-4 3,3'-dinitroazobenzene 
• 958-96-3 3,3'-dinitro-1,1'-biphenyl 
• 98-95-3 nitrobenzene 
• 2113-58-8 3-nitro-1,1'-biphenyl 
• 585-79-5 m-nitrobromobenzene 
• 63312-08-3 [IrCl₂(m-N₂C₆H₄NO₂)(CO)(PPh₃)2] 
• 63312-09-4 [IrCl₂(N₂C₆H₃F₂-2,6)(CO)(PPh₃)2] 
• 1182278-46-1 (E)-4-(3-nitrophenyl)but-3-ene-1,2-diyl diacetate 
• 39896-32-7 1-(3-nitrophenyl)propan-2-one 
• 618-95-1 methyl 3-nitrobenzoate 
• 10268-12-9 methyl 3-nitrophenylacetate 

Relevant articles and documents

Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO)

Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO), which mediate kynurenine pathway of tryptophan degradation, have emerged as potential new targets in immunotherapy for treatment of cancer because of their critical role in immunosuppression in the tumor microenvironment. In this investigation, we report the structural optimization and structure-activity relationship studies of 1-phenyl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as a new class of IDO1/TDO dual inhibitors. Among all the obtained dual inhibitors, 1-(3-chloro-4-fluorophenyl)-6-fluoro-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione (38) displayed the most potent IDO1 and TDO inhibitory activities with IC50 (half-maximal inhibitory concentration) values of 5 nM for IDO1 and 4 nM for TDO. It turned out that compound 38 was not a PAINS compound. Compound 38 could efficiently inhibit the biofunction of IDO1 and TDO in intact cells. In LL2 (Lewis lung cancer) and Hepa1-6 (hepatic carcinoma) allograft mouse models, this compound also showed considerable in vivo anti-tumor activity and no obvious toxicity was observed. Therefore, 38 could be a good lead compound for cancer immunotherapy and deserving further investigation.

Copper(I)-promoted trifluoromethylthiolation of arenediazonium salts with AgSCF3

An efficient method for trifluoromethylthiolation of arenediazonium salts has been developed in mild conditions with a stable and convenient AgSCF3. It provides a straightforward and convenient way for the synthesis of trifluoromethylthiolated compound from diazonium salts in moderate to good yields.

Visible-Light-Mediated Hydroxycarbonylation of Diazonium Salts

A visible light-promoted catalytic photoredox hydroxycarbonylation was achieved on aryl diazonium salts whether preformed or generated in situ from the corresponding anilines. This strategy allows a straightforward access to a variety of carboxylic acids under mild conditions. (Figure presented.).