58633-04-8

Basic information

• Product Name: 4-Amino-3,5-dibromobenzonitrile
• Synonyms: 2,6-Dibromo-4-cyanoaniline;3,5-Dibromo-4-aminobenzonitrile;4-Cyano-2,6-dibromoaniline
• CAS NO: 58633-04-8
• Molecular Formula: C₇H₄Br₂N₂
• Molecular Weight: 275.94
• Mol File: 58633-04-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 124-126℃
• Boiling Point: 312℃
• Flash Point: 113℃
• Appearance: /
• Density: 2.12
• Vapor Pressure: 0.000555mmHg at 25°C
• Refractive Index: 1.704
• Storage Temp.: 2-8°C(protect from light)
• PKA: -2.40±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-3,5-dibromobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3,5-dibromobenzonitrile(58633-04-8)
• EPA Substance Registry System: 4-Amino-3,5-dibromobenzonitrile(58633-04-8)

Safety Data

• Hazardous Substances Data: 58633-04-8(Hazardous Substances Data)

Usage

General Description

4-Amino-3,5-dibromobenzonitrile is a chemical compound with the molecular formula C7H3Br2N. It is a white to off-white solid at room temperature and is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 4-Amino-3,5-dibromobenzonitrile is soluble in organic solvents like acetone, ethanol, and methanol, but has limited solubility in water. It is also known to be an intermediate in the production of dyes and pigments and is used in research and development in the chemical and pharmaceutical industries. The compound is primarily synthesized through a simple reaction between 3,5-dibromobenzonitrile and ammonia, and it is commonly handled and stored in accordance with standard laboratory practices for handling hazardous chemicals.

InChI:InChI=1/C7H4Br2N2/c8-5-1-4(3-10)2-6(9)7(5)11/h1-2H,11H2

Upstream product

• 873-74-5 4-Aminobenzonitrile 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 54381-73-6 C₇H₃Br₂N₃O₂ 
• 98278-79-6 2,6-Dibrom-4-cyano-nitrosobenzol 
• 203051-50-7 2'-(3,5-Dichloro-phenylsulfanylamino)-[1,1';3',1'']terphenyl-5'-carbonitrile 
• 107829-04-9 N-[5-Diethylamino-2-(2,4,6-tricyano-phenylazo)-phenyl]-acetamide 
• 107828-98-8 N-[2-(2,6-Dicyano-4-nitro-phenylazo)-5-dipropylamino-phenyl]-benzamide 
• 105170-52-3 3,5-dibromo-4-iodobenzonitrile 
• 1155287-11-8 (2,6-dibromo-4-cyano-phenyl)-thiourea 
• 1261225-77-7 4-amino-3,5-dicyclopropylbenzonitrile 
• 97165-77-0 3,5-dibromobenzonitrile 

Relevant articles and documents

SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS

Described herein are compounds of Formula (I), Formula (I-A), and Formula (I-B), solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing, Further described herein are methods of inhibiting NLRP3 using said compounds, and methods of and compositions useful in treating NLRP3-dependent disorders.

1,1,2,2-Tetrahydroperoxy-1,2-Diphenylethane: An efficient and high oxygen content oxidant in various oxidative reactions

Several oxidative approaches namely thiocyanation of aromatic compounds, epoxidation of alkenes, amidation of aromatic aldehydes, epoxidation of α β-unsaturated ketones, oxidation of sulfides to sulfoxides and sulfones, bayer-villeger reaction, bromination and iodation of aniline and phenol derivatives oxidative esterification, oxidation of pyridines and oxidation of secondary, allylic and benzyllic alcohols were carried out using 1,1,2,2-Tetrahydroperoxy-1,2-Diphenylethane as the potential solid oxidant which can be stored for several months without any loss in its activity. All of the procedures were accomplished via mild reaction conditions and the products were afforded in high yields and short reaction times.

Fast and efficient bromination of aromatic compounds with ammonium bromide and Oxone

A highly efficient, rapid and regioselective protocol was developed for the ring bromination of aromatic compounds under mild conditions with ammonium bromide as a source of bromine source and Oxone (potassium peroxysulfate) as an oxidant. No metal catalyst or acidic additive is required. A variety of aromatic compounds, including methoxy, hydroxy, amino, and alkyl arenes, reacted smoothly to give the corresponding monobrominated products in good to excellent yields in very short reaction times. Moreover, dibromination of deactivated anilines to give the corresponding dibromides proceeded in high yields. Interestingly, 1-(2-naphthyl)ethanone provided a ring-brominated product. Georg Thieme Verlag Stuttgart . New York.