58655-30-4

Basic information

• Product Name: C₆H₁₅N*C₉H₁₁NS₂
• Synonyms: C₆H₁₅N*C₉H₁₁NS₂
• CAS NO: 58655-30-4
• Molecular Weight: 298.517
• Mol File: 58655-30-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₆H₁₅N*C₉H₁₁NS₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₆H₁₅N*C₉H₁₁NS₂(58655-30-4)
• EPA Substance Registry System: C₆H₁₅N*C₉H₁₁NS₂(58655-30-4)

Safety Data

• Hazardous Substances Data: 58655-30-4(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 95-64-7 4-amino-o-xylene 

Downstream Products

• 16738-18-4 N-(3,4-dimethylphenyl)thiourea 
• 70590-11-3 (3,4-dimethylphenyl)cyanamide 
• 19241-17-9 3,4-xylyl isothiocyanate 

Relevant articles and documents

Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity

A series of N,4-diaryl-1,3-thiazole-2-amines containing three aromatic rings with an amino linker were designed and synthesized as tubulin inhibitors and evaluated for their antiproliferative activity in three human cancer cell lines. Most of the target compounds displayed moderate antiproliferative activity, and N-(2,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-1,3-thiazol-2-amine (10s) was determined to be the most potent compound. Tubulin polymerization and immunostaining experiments revealed that 10s potently inhibited tubulin polymerization and disrupted tubulin microtubule dynamics in a manner similar to CA-4. Moreover, 10s effectively induced SGC-7901 cell cycle arrest at the G2/M phase in both concentrationand time-dependent manners. The molecular docking results revealed that 10s could bind to the colchicine binding site of tubulin.