588-36-3

Basic information

• Product Name: (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL
• Synonyms: (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)ME...;(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL;(4-AMINO-2-METHYLSULFANYL-PYRIMIDIN-5-YL)-METHANOL;4-AMINO-2-METHYLMERCAPTO-PYRIMIDINE-4-CARBINOL;4-AMINO-2-(METHYLTHIO)-5-PYRIMIDINEMETHANOL;4-AMINO-5-HYDROXYMETHYL-2-(METHYLTHIO)PYRIMIDINE;Methioprim;(4-azanyl-2-methylsulfanyl-pyrimidin-5-yl)methanol
• CAS NO: 588-36-3
• Molecular Formula: C₆H₉N₃OS
• Molecular Weight: 171.22
• Product Categories: Amines;Aromatics;Heterocycles;Sulfur & Selenium Compounds
• Mol File: 588-36-3.mol
• Article Data: 33

Chemical Properties

• Melting Point: 126-127°
• Boiling Point: 408.6 °C at 760 mmHg
• Flash Point: 200.9 °C
• Appearance: /
• Density: 1.38 g/cm³
• Vapor Pressure: 2.07E-07mmHg at 25°C
• Refractive Index: 1.646
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 13.08±0.10(Predicted)
• CAS DataBase Reference: (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL(588-36-3)
• EPA Substance Registry System: (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL(588-36-3)

Safety Data

• Hazardous Substances Data: 588-36-3(Hazardous Substances Data)

Usage

Description

(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL is a white crystalline powder that serves as an intermediate in the synthesis of various compounds, including Thiamine (T344185), pyridopyrimidines, and naphthyridines. These synthesized compounds have potential applications in the treatment of cancer and other diseases.

Uses

Used in Pharmaceutical Industry:
(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL is used as an intermediate for the synthesis of Thiamine (T344185), which is essential for various biological processes and has applications in the pharmaceutical industry.
Used in Cancer Treatment:
(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL is used in the preparation of pyridopyrimidines and naphthyridines, which are inhibitors of Akt kinase. These compounds have potential applications in the treatment of cancer, as they can help regulate cellular processes and inhibit tumor growth.
Used in Tumor Antagonist Research:
(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL has been identified as a tumor antagonist in mice, indicating its potential use in the development of new cancer therapies and treatments.
Chemical Properties:
(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL is a white crystalline powder, which is a characteristic of its chemical structure and properties.

InChI:InChI=1/C6H9N3OS/c1-11-6-8-2-4(3-10)5(7)9-6/h2,10H,3H2,1H3,(H2,7,8,9)

Upstream product

• 776-53-4 ethyl 4-amino-2-methylmercaptopyrimidine-5-carboxylate 
• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 
• 774-07-2 ethyl 4-amino-2-thioxo-1H-pyrimidine-5-carboxylate 
• 771-81-3 4-amino-2-(methylthio)pyrimidine-5-carboxylic acid 

Downstream Products

• 1123-95-1 5-hydroxymethylcytosine 
• 770-31-0 4-amino-2-(methylthio)pyrimidine-5-carbaldehyde 
• 850628-90-9 4-[4-(8-isopropyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]piperazine-1-carboxylic acid tert-butyl ester 
• 352328-55-3 1-(4-amino-2-methylsulfanylpyrimidin-5-yl)ethanone 
• 850628-76-1 5-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 211244-82-5 8-ethyl-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 211244-93-8 2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one 
• 211245-79-3 8-Cyclohexyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 211245-16-8 8-ethyl-2-(4-hydroxyphenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one 
• 211245-80-6 8-cyclohexyl-2-(methanesulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 211245-12-4 8-ethyl-2-(4-methoxyphenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one 

Relevant articles and documents

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Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling

Receptor interacting protein kinase-2 (RIPK2) is an enzyme involved in the transduction of pro-inflammatory nucleotide-binding oligomerization domain (NOD) cell signaling, a pathway implicated in numerous chronic inflammatory conditions. Herein, a pyrido[

Pyrido[2,3-d]pyrimidin-7(8H)-one derivatives and Composition for skin whitening and Pharmaceutical composition for use in preventing or treating disorders of Melanin Hyperpigmentation containing the same as an active ingredient

The present invention relates to a pyrido[2,3-d]pyrimidin-7(8H)-one derivative, and to a composition for skin whitening comprising the same as an active ingredient. Since the derivative exhibits an effect of inhibiting the production of melanin even when

PROTEIN KINASE INHIBITORS AND USES THEREOF FOR THE TREATMENT OF DISEASES AND CONDITIONS

Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2) and/or receptor interacting kinase 3 (RIPK3). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 or RIPK3 could provide therapeutic benefit. Compounds that function as RIPK3 inhibitors provide therapeutic benefit in the treatment of inflammatory and degenerative conditions.