58895-64-0 Usage
Description
Nalmefene hydrochloride, also known by the brand name Revex, is a potent opioid antagonist that is structurally similar to naltrexone. It is characterized by its higher potency, longer duration of action, and superior bioavailability compared to naltrexone. Nalmefene hydrochloride is primarily used for opioid reversal following surgery, in the treatment of opioid overdoses, and for the management of epidurally administered narcotics. It exhibits a wide spectrum of biological activity and is currently in clinical trials for various conditions, including interstitial cystitis, pruritus of cholestasis, stroke, rheumatoid arthritis, shock, CNS trauma, and alcoholism. Notably, nalmefene does not induce morphine-like effects and has no apparent abuse potential.
Uses
Used in Pharmaceutical Industry:
Nalmefene hydrochloride is used as an opioid antagonist for the treatment of alcoholism. It helps reduce cravings for alcohol and is effective in managing opioid dependence.
Used in Veterinary Industry:
In the veterinary field, nalmefene hydrochloride is utilized as an opioid-induced tranquilizer for large animals, providing relief from the effects of opioids and ensuring the safety and well-being of the animals.
Used in Clinical Trials:
Nalmefene hydrochloride is being investigated in clinical trials for its potential applications in treating various conditions such as interstitial cystitis, recalcitrant pruritus of cholestasis, stroke, rheumatoid arthritis, shock, CNS trauma, and alcoholism. Its wide spectrum of biological activity makes it a promising candidate for these therapeutic areas.
Used in Opioid Reversal:
Nalmefene hydrochloride is employed as an opioid antagonist in the reversal of opioid overdoses, helping to counteract the respiratory, analgesic, and subjective effects of opioids and potentially saving lives in emergency situations.
Used in Post-surgical Care:
Following surgery, nalmefene hydrochloride is used to reverse the effects of opioids administered during the procedure, ensuring a smoother recovery process for patients and reducing the risk of opioid-related complications.
Originator
IVAX (U.S.A.)
References
1) Osborn et al. (2010), In vivo characterization of the opioid antagonist nalmefene in mice; Life Sci., 86 624
2) Butelman et al. (2009), Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in non-human primates: fast onset and entry in cerebrospinal fluid; J. Pharmacol. Exp. Ther., 328 588
3) Butelman et al. (2008), The effects of herkinorin, the first mu-selective ligand from salvinorin A-derived scaffold, in neuroendocrine biomarker assay in nonhuman primates; J. Pharmacol. Exp. Ther., 327 154
4) Soyka and Rosner (2008), Opioid antagonists for pharmacological treatment of alcohol dependence – a critical review; Curr. Drug Abuse Rev., 1 280
Check Digit Verification of cas no
The CAS Registry Mumber 58895-64-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,8,9 and 5 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 58895-64:
(7*5)+(6*8)+(5*8)+(4*9)+(3*5)+(2*6)+(1*4)=190
190 % 10 = 0
So 58895-64-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H25NO3.ClH/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13;/h4-5,13,16,19,23-24H,1-3,6-11H2;1H/t16-,19+,20+,21-;/m1./s1
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