58905-19-4

Basic information

• Product Name: 1-(4-CHLOROPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE
• Synonyms: 1-(4-CHLOROPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE;1-(4-chlorophenyl)-2-(1,2,4-triazol-1-yl)ethanone;1-(4-Chloro-phenyl)-2-[1,2,4]triazol-1-yl-ethanone;BAS 00654784;Bionet2_001558;EU-0033550;ST025306;ZINC00114273
• CAS NO: 58905-19-4
• Molecular Formula: C₁₀H₈ClN₃O
• Molecular Weight: 221.64
• Mol File: 58905-19-4.mol
• Article Data: 39

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-CHLOROPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLOROPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE(58905-19-4)
• EPA Substance Registry System: 1-(4-CHLOROPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE(58905-19-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 58905-19-4(Hazardous Substances Data)

Usage

Chemical Structure

A ketone derivative containing a 1,2,4-triazole ring and a chlorophenyl group

Pharmaceutical

Used as a building block in the synthesis of other biologically active compounds

Agricultural

Utilized in various agricultural applications

Medicinal Chemistry

Potential applications in the field of medicinal chemistry

Hazards

It is important to handle and use this chemical with care due to certain hazards associated with its use.

Upstream product

• 288-88-0 1,2,4-Triazole 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 128136-93-6 1-(4-chlorophenyl)-2-(1,2,4-4H-triazol-4-yl)ethanone 
• 126961-65-7 1-(4-chlorophenacyl)-4-amino-1H-1,2,4-triazolium bromide 
• 937-20-2 p-chlorophenacyl chloride 
• 99-91-2 para-chloroacetophenone 
• 108-90-7 chlorobenzene 
• 41253-21-8 sodium triazole 

Downstream Products

• 81886-49-9 1,3-bis(1H-1,2,4-triazol-1-yl)-2-(4-chlorophenyl)-2-propanol 
• 104940-90-1 1-(4-Chloro-phenyl)-2-[1,2,4]triazol-1-yl-propenone 
• 119393-53-2 1-(4-chlorophenyl)-N-methyl-2-(1H-1,2,4-triazol-1-yl)-ethanimine N-oxide 
• 110762-97-5 2-(4-chlorophenyl)-2-(1,2,4-triazole-1-ylmethyl)-4-hydroxymethyl-1,3-dioxolane 
• 62881-59-8 1-p-chlorophenyl-2-(1,2,4-triazol-1-yl)ethanol 
• 225645-28-3 (E)-1-(4-chlorophenyl)-3-(3,4-methylenedioxyphenylmethylene)-2-(1,2,4-triazol-1-yl)prop-2-en-1-one 
• 63334-23-6 (E)-1,3-bis(4-chlorophenyl)-2-(1,2,4-triazol-1-yl)prop-2-en-1-one 

Relevant articles and documents

Synthesis of the Methanesulfonates of α-(4-Chlorophenyl)-α-[1-(2-chlorophenyl)ethenyl]-1H-1,2,4-triazole- 1-ethanol and α-[1-(2-Chlorophenyl)ethenyl]-α-(2,4-difluorophenyl)- 1H-1,2,4-triazole-1-ethanol, Aloha Styryl Carbinol Antifungal Agents

The methanesulfonates of (α-(4-chlorophenyl)-α-[1-(2-chlorophenyl)ethenyl]-1H-1,2,4-triazole- l-ethanoI and α-[1-(2-chlorophenyl)ethenyl]-α-(2,4-difluorophenyl)-1H-1,2,4- triazole-1-ethanol (1a,b) are orally effective α-styryl carbinol derivatives develop

Triazole derivative as well as preparation method and application thereof

The invention relates to a triazole derivative as well as a preparation method and application thereof, which belong to the technical field of organic synthetic drugs. The structure of the triazole derivative is shown as a formula I. In the formula I, R1 and R2 are H, Cl, Br,-CF3,-CH(CH3)2 or -OCH3, and R1 and R2 are not H at the same time. R3 is -CH2 or -COCH2; X and Y are N or C, X and Y are not C at the same time, and X and Y are not N at the same time. The triazole derivative disclosed by the invention has a certain inhibition effect on germs of various crop diseases. Small toxic andside effects on plants are achieved. The preparation method of the triazole derivative is simple.

Method for preparing cyproconazole with 2,4'-dichloroacetophenone being raw material

The invention relates to the field of organic synthesis and especially relates to a method for preparing cyproconazole with 2,4'-dichloroacetophenone being a raw material. The method includes: a) performing a nucleophilic substitution reaction on the 2,4'-dichloroacetophenone and 1,2,4-triazole or 1,2,4-triazole salt to obtain 1-(4-chlorophenyl)-2-(1H-1,2,4-triazole-1-yl)ethyl ketone; b) performing a nucleophilic addition reaction on the 1-(4-chlorophenyl)-2-(1H-1,2,4-triazole-1-yl)ethyl ketone with one or more of a 3-halogenated-1-butylene Grignard reagent, a 3-halogenated-1-butylene organozinc reagent, a 1-halogenated-2-butylene Grignard reagent and a 1-halogenated-2-butylene organozinc reagent, thus generating 2-(4-chlorophenyl)-3-methyl-1-(1H-1,2,4-triazole-1-yl)-4-pentene-2-ol; c) performing a ring forming reaction on the 2-(4-chlorophenyl)-3-methyl-1-(1H-1,2,4-triazole-1-yl)-4-pentene-2-ol with one or more Simmons-Smith reagents prepared from dihalogenated methane, thus preparing the cyproconazole. The preparation method is short in route, gentle in reaction and high in yield. The reactions are free of dangerous reagents, so that the method is suitable for large scale industrial production.