58915-09-6

Basic information

• Product Name: ethyl 4-{[(1,3-benzoxazol-2-ylsulfanyl)acetyl]amino}benzoate
• Synonyms: benzoic acid, 4-[[2-(2-benzoxazolylthio)acetyl]amino]-, ethyl ester; ethyl 4-{[2-(1,3-benzoxazol-2-ylthio)acetyl]amino}benzoate
• CAS NO: 58915-09-6
• Molecular Formula: C₁₈H₁₆N₂O₄S
• Molecular Weight: 356.3956
• Mol File: 58915-09-6.mol
• Article Data: 1

Chemical Properties

• Density: 1.36g/cm³
• Refractive Index: 1.654
• CAS DataBase Reference: ethyl 4-{[(1,3-benzoxazol-2-ylsulfanyl)acetyl]amino}benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-{[(1,3-benzoxazol-2-ylsulfanyl)acetyl]amino}benzoate(58915-09-6)
• EPA Substance Registry System: ethyl 4-{[(1,3-benzoxazol-2-ylsulfanyl)acetyl]amino}benzoate(58915-09-6)

Safety Data

• Hazardous Substances Data: 58915-09-6(Hazardous Substances Data)

Upstream product

• 26226-72-2 4-[(chloroacetyl)amino]-benzoic acid, ethyl ester 
• 2382-96-9 2-sulfanyl-1,3-benzoxazole 

Downstream Products

• 58915-15-4 2-benzooxazol-2-ylsulfanyl-N-(4-hydrazinocarbonyl-phenyl)-acetamide 

Relevant articles and documents

Synthesis of substituted thiobenzoxazoles/benzothiazoles: inhibition of cellular respiratory and monoamine oxidase activities and anticonvulsant property

Several 2 (substituted alkoxy/hydrazinocarbonyl acetanilidothio) benzoxazoles/benzothiazoles were synthesized and characterized by their sharp melting points, elemental analyses, and IR spectra. All thiobenzoxazoles/benzothiazoles possessed low anticonvulsant activity, which was reflected by the 10-40% protection afforded by these compounds against pentylenetetrazol induced convulsions. All thiobenzoxazoles/benzothiazoles inhibited selectively the nicotinamide adenine dinucleotide (NAD) dependent oxidation of pyruvate, DL isocitrate, and α ketoglutarate by rat brain homogenates. NAD independent oxidation of succinate remained unaltered. All 2 (substituted hydrazinocarbonyl acetanilidothio) benzoxazoles/benzothiazoles inhibited monoamine oxidase activity of rat brain homogenates. Greater monoamine oxidase inhibition was observed with thiobenzothiazoles than with the corresponding thiobenzoxazoles. The low anticonvulsant activity possessed by these thiobenzoxazoles/benzothiazoles was found to be unrelated with their ability to inhibit cellular respiratory and monoamine oxidase activities of rat brain homogenates.