59010-46-7

Basic information

• Product Name: SALOR-INT L497967-1EA
• Synonyms: SALOR-INT L497967-1EA;4-(2-HYDROXY-4-METHYLPHENYL)-4-OXOBUTANOIC ACID
• CAS NO: 59010-46-7
• Molecular Weight: 208.214
• Mol File: 59010-46-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: SALOR-INT L497967-1EA(CAS DataBase Reference)
• NIST Chemistry Reference: SALOR-INT L497967-1EA(59010-46-7)
• EPA Substance Registry System: SALOR-INT L497967-1EA(59010-46-7)

Safety Data

• Hazardous Substances Data: 59010-46-7(Hazardous Substances Data)

Upstream product

• 857229-77-7 4-(5-chloro-2-methoxy-4-methyl-phenyl)-4-oxo-butyric acid 
• 13334-71-9 1-chloro-4-methoxy-2-methylbenzene 
• 59-50-7 4-Chloro-3-methylphenol 
• 59010-47-8 Methyl 4-(2-Hydroxy-4-methylphenyl)-4-oxobutanoate 
• 108-30-5 succinic acid anhydride 
• 3228-03-3 3-isopropyl-5-methylphenol 
• 62903-21-3 4-(5-Chloro-2-hydroxy-4-methylphenyl)-4-oxobutanoic Acid 
• 91497-61-9 4-(2-methoxy-4-methyl-phenyl)-4-oxo-butyric acid 
• 108-39-4 3-methyl-phenol 
• 127275-12-1 4-Chloro-3-methylphenyl Hydrogen Succinate 

Downstream Products

• 71945-73-8 4-(2-hydroxy-4-methylphenyl)-butyric acid 
• 39499-70-2 6-(2-hydroxy-4-methyl-phenyl)-4,5-dihydro-2H-pyridazin-3-one 
• 100613-20-5 4-(2-methoxy-4-methyl-phenyl)-4-oxo-butyric acid methyl ester 
• 605674-54-2 4-(2-methoxy-4-methylphenyl)-2-methylbutyric acid 
• 105402-00-4 4-(2-methoxy-4-methylphenyl)butyric acid 

Relevant articles and documents

Synthesis of (+/-)-hamigeran B, (-)-hamigeran B, and (+/-)-1-epi-hamigeran B: use of bulky silyl groups to protect a benzylic carbon-oxygen bond from hydrogenolysis.

Enone 42 was converted into diene 56, which was then subjected to hydrogenation. Use of the tert-butyldimethylsiloxy groups enforces facial selectivity and protects the C(5) oxygen from hydrogenolysis. The resulting product (55) is easily converted into hamigeran B (1), a marine natural product with powerful activity against herpes and polio viruses. Optically pure enone 73 was made by use of a Meyers' auxiliary and converted into (-)-hamigeran B with the natural absolute configuration.

Synthesis of rac-Cinera-5,7,11-trien-9-one

The spiro trienone 22 isolated from a Cineraria species has been synthesized as racemate by intramolecular alkylation starting with 5-isopropyl-3-methylphenol via a suitable phenol substituted in position 2.This compound gave no Diels-Alder reaction with