59032-27-8 Usage
Description
Sodium 1,2,3-triazole-5-thiolate, also known as 5-Mercapto-1H-1,2,3-triazole Sodium Salt, is an organic compound with the chemical formula C2H3N3NaS. It is a derivative of 1,2,3-triazole, a five-membered heterocyclic compound containing three nitrogen atoms and one sulfur atom. Sodium 1,2,3-triazole-5-thiolate is a white crystalline solid that is soluble in water and has a molecular weight of 129.13 g/mol.
Uses
Used in Pharmaceutical Industry:
Sodium 1,2,3-triazole-5-thiolate is used as a reactant in the preparation of cephem derivatives, which are anti-Helicobacter pylori agents. These cephem derivatives exhibit lability towards β-lactamase, an enzyme produced by H. pylori that can break down penicillin and other β-lactam antibiotics, rendering them ineffective. By incorporating Sodium 1,2,3-triazole-5-thiolate into the cephem structure, the resulting compounds can overcome this resistance and effectively target H. pylori, a bacterium that can cause peptic ulcers and gastric cancer.
Furthermore, cephem derivatives prepared with Sodium 1,2,3-triazole-5-thiolate have the potential for causing diarrhea, which can be beneficial in certain clinical situations where the expulsion of the bacteria from the gastrointestinal tract is desired. This dual action of being resistant to β-lactamase and promoting diarrhea makes Sodium 1,2,3-triazole-5-thiolate an important component in the development of novel anti-Helicobacter pylori agents.
Check Digit Verification of cas no
The CAS Registry Mumber 59032-27-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,0,3 and 2 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 59032-27:
(7*5)+(6*9)+(5*0)+(4*3)+(3*2)+(2*2)+(1*7)=118
118 % 10 = 8
So 59032-27-8 is a valid CAS Registry Number.
InChI:InChI=1/C2H3N3S/c6-2-1-3-5-4-2/h1H,(H2,3,4,5,6)/p-1
