5909-59-1Relevant articles and documents
Discovery of a new autophagy inducer for A549 lung cancer cells
Li, Na,Qu, GuoJing,Xue, JingNa,Li, Xiao,Zhao, Xuan,Yan, YeHao,Gao, DongFang,Zhang, Lu,Wang, Peng,Zhang, Ming,Zhao, BaoXiang,Miao, JunYing,Lin, ZhaoMin
, p. 2845 - 2856 (2019)
Biological activities of a series of fluorescent compounds against human lung cancer cell line A549 were investigated. The results showed that (E)-1,3,3-trimethyl-2-(4-(piperidin-1-yl)styryl)-3H-indol-1-ium iodide (8) and (E)-2-(5,5-dimethyl-3-(4-(piperazin-1-yl)styryl)cyclohex-2-en-1-ylidene) malononitrile (11) could inhibit the growth of A549 cancer cells in a dose and time-dependent manner. Furthermore, compound 8 could trigger autophagy and apoptosis, but not obviously induce necrosis under the stimulatory condition. Therefore, 8 can be used as autophagy activator to investigate the regulatory mechanism of autophagy and may offer a new candidate for the treatment of lung cancer.
Poly(Pyrrole-Phenothiazine) Modified Electrodes. Application as Photoelectrodes via a Charge Transfer Complex
Deronzier, Alain,Essakalli, Mohamed,Moutet, Jean-Claude
, p. 773 - 775 (1987)
Electrodes modified by a poly(pyrrole-phenothiazine) film are obtained by anodic polymerization of N-(3-pyrrol-1-ylpropyl)phenothiazine; they act as photoelectrodes via their charge transfer complex with an electron acceptor in solution.
Phenothiazine compound as well as preparation method and application thereof
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Paragraph 0041-0044, (2021/08/19)
The invention discloses a phenothiazine compound which has the advantages of novel structural general formula and framework, high efficiency, low toxicity and better inhibitory activity on LSD1. The invention also discloses a preparation method of the compound. The preparation method has the characteristics of mild reaction conditions, simplicity in operation and high reaction yield. According to the invention, phenothiazine is taken as a raw material, active groups are respectively introduced to a parent of phenothiazine, and new phenothiazine pharmacophores are synthesized; and phenothiazine compounds are designed and synthesized by modification with piperazine, morpholine, piperidine and other groups. The compound retains the activity of phenothiazine and also has the characteristics of modification groups, so that the biological activity of original molecules is improved, and the anti-tumor activity of target molecules is improved. The invention also discloses an application of the compound in preparation of LSD1-targeted antitumor drugs, and the compound shows good inhibitory activity on LSD1 and shows good development potential.
Phenothiazine compound and application thereof
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Paragraph 0122-0125, (2019/06/07)
The invention provides a phenothiazine compound and application thereof to preparation of drugs for curing breast cancer and melanoma. The phenothiazine compound has higher inhibitory activity on thebreast cancer cell MDA- MB- 231, SUM159, MCF- 7, SKBR- 3 and the melanoma cell A375 and B16BL6 than trifluoperazine and thioridazine, and can be applied to curing breast cancer and melanoma. The general formula of the phenothiazine compound is as following (the formula is shown in the description), wherein R1 and R2 are as shown in the description.