59184-12-2

Basic information

• Product Name: 4-mesityl-3,5-dimethylisoxazole
• Synonyms: 4-mesityl-3,5-dimethylisoxazole
• CAS NO: 59184-12-2
• Molecular Weight: 215.295
• Mol File: 59184-12-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-mesityl-3,5-dimethylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-mesityl-3,5-dimethylisoxazole(59184-12-2)
• EPA Substance Registry System: 4-mesityl-3,5-dimethylisoxazole(59184-12-2)

Safety Data

• Hazardous Substances Data: 59184-12-2(Hazardous Substances Data)

Upstream product

• 10558-25-5 4-bromo-3,5-dimethyl-1,2-oxazole 
• 2633-66-1 2-mesitylmagnesium bromide 
• 5980-97-2 mesitylboronic acid 
• 832114-00-8 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole 
• 576-83-0 2,4,6-trimethylphenyl bromide 
• 71183-35-2 3-(2',4',6'-trimethylphenyl)-2,4-pentanedione 

Relevant articles and documents

[PdA (IPr*) (cinnamyl)Cl]: An efficient pre-catalyst for the preparation of tetra-ortho-substituted biaryls by Suzuki-Miyaura cross-coupling

The bigger the better: The new well-defined [Pd(IPr*)(cin)Cl] pre-catalyst is described (see scheme). This complex proves to be highly active in the Suzuki-Miyaura cross-coupling for the synthesis of tetra-ortho- substituted biaryls under mild conditions.

Pd-PEPPSI-IPent: Low-temperature negishi cross-coupling for the preparation of highly functionalized, tetra-ortho-substituted biaryls

(Chemical Equation Presented) Cool couplings: Complex, hindered biaryls have been prepared at temperatures ranging from 0°C to room temperature, or with gentle heating. The Pd-PEPPSI-IPent catalyst (see scheme) nicely couples starting materials containing acidic moieties and routinely prepares biaryl derivatives where one or both rings comprising the biaryl are heterocyclic. Ar1=hindered aryl or heteroaryl, Ar2=unactivated aryl or heteroaryl.