59216-77-2

Basic information

• Product Name: METHYL 5-HYDROXY-2-NITROBENZOATE
• Synonyms: METHYL 5-HYDROXY-2-NITROBENZOATE;RARECHEM AL BF 0679;5-Hydroxy-2-nitro-benzoic acid methyl ester
• CAS NO: 59216-77-2
• Molecular Formula: C₈H₇NO₅
• Molecular Weight: 197.14
• Product Categories: Aromatic Esters
• Mol File: 59216-77-2.mol
• Article Data: 18

Chemical Properties

• Melting Point: 114-115 °C
• Boiling Point: 381.8±27.0 °C(Predicted)
• Appearance: /
• Density: 1.432±0.06 g/cm3(Predicted)
• PKA: 6.26±0.10(Predicted)
• CAS DataBase Reference: METHYL 5-HYDROXY-2-NITROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-HYDROXY-2-NITROBENZOATE(59216-77-2)
• EPA Substance Registry System: METHYL 5-HYDROXY-2-NITROBENZOATE(59216-77-2)

Safety Data

• Hazardous Substances Data: 59216-77-2(Hazardous Substances Data)

Usage

Description

METHYL 5-HYDROXY-2-NITROBENZOATE, a nitrobenzoate derivative with the molecular formula C8H7NO5, is a yellow solid chemical compound commonly utilized in organic synthesis and pharmaceutical research. It serves as an intermediate in the production of various drugs and active pharmaceutical ingredients, as well as in the manufacturing of dyes, pigments, and other organic compounds. Due to its potential hazards, it is crucial to handle METHYL 5-HYDROXY-2-NITROBENZOATE with care and adhere to proper safety protocols.

Uses

Used in Pharmaceutical Industry:
METHYL 5-HYDROXY-2-NITROBENZOATE is used as an intermediate in the synthesis of various drugs and active pharmaceutical ingredients for its ability to contribute to the development of new medications.
Used in Chemical Industry:
METHYL 5-HYDROXY-2-NITROBENZOATE is used as a component in the manufacturing of dyes and pigments, playing a role in the production of colorants for different applications.
Used in Organic Synthesis:
METHYL 5-HYDROXY-2-NITROBENZOATE is used as a reagent in organic synthesis processes, facilitating the creation of a range of organic compounds for various purposes.

Upstream product

• 67-56-1 methanol 
• 610-37-7 5-hydroxy-2-nitrobenzoic acid 
• 99-06-9 3-Carboxyphenol 
• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 

Downstream Products

• 499973-04-5 methyl 2-nitro-5-(prop-2-ynyloxy)benzoate 
• 499973-05-6 2-nitro-5-(prop-2-ynyloxy)benzoic acid 
• 499973-06-7 N-(2-nitro-5-(prop-2-ynyloxy)benzoyl)-L-proline methyl ester 
• 485824-59-7 methyl 2-nitro-5-(thien-2-ylmethoxy)benzoate 
• 4315-16-6 5-hydroxy-2-nitrobenzamide 
• 116027-16-8 methyl 5-(benzyloxy)-2-nitrobenzoate 
• 951666-08-3 2-Nitro-5-(4-nitro-phenoxy)-benzoic acid methyl ester 
• 1882-72-0 methyl 2-amino-5-hydroxybenzoate 
• 1276040-19-7 C₁₃H₈F₃N₃O₄ 
• 1276040-20-0 C₁₃H₁₀F₃N₃O₂ 
• 1276040-21-1 C₂₁H₁₈F₃N₃O₂ 
• 1276035-58-5 C₂₂H₁₆F₃N₃O₂ 
• 1276035-64-3 C₂₁H₁₃ClF₃N₃O₂ 
• 1276035-80-3 C₂₃H₁₈F₃N₃O₂ 

Relevant articles and documents

Preparation technology of 6-hydroxy-bentazone

The invention discloses a preparation technology of 6-hydroxy-3-isopropyl-1H-benzo[c][1,2,6]thiadiazine-4(3H)-keto-2,2-dioxide. The preparation technology includes subjecting 5-chloro-2-nitrobenzoic acid serving as a raw material to hydrolysis reaction an

Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists

Herein, we report studies leading to the discovery of the neoseptins and a comprehensive examination of the structure-activity relationships (SARs) of this new class of small-molecule mouse Toll-like receptor 4 (mTLR4) agonists. The compounds in this class, which emerged from screening an α-helix mimetic library, stimulate the immune response, act by a well-defined mechanism (mouse TLR4 agonist), are easy to produce and structurally manipulate, exhibit exquisite SARs, are nontoxic, and elicit improved and qualitatively different responses compared to lipopolysaccharide, even though they share the same receptor.

NEOSEPTINS: SMALL MOLECULE ADJUVANTS

A MD-2:TLR4 complex agonist compound is disclosed whose structure corresponds to Formula (I), as defined within. Also disclosed are a method of its preparation and use, as well as a pharmaceutical composition containing the same.