5928-51-8

Basic information

• Product Name: 3-(2-THIENYL)PROPIONIC ACID
• Synonyms: 3-THIOPHEN-2-YL-PROPIONIC ACID;AKOS B029955;3-(2-THIENYL)PROPANOIC ACID;3-(2-THIENYL)PROPIONIC ACID;BUTTPARK 51\07-23;3-(2-THIENYL)PROPOINIC ACID ;2-thiophenepropionic acid;2-Thiophenepropanoic acid.
• CAS NO: 5928-51-8
• Molecular Formula: C₇H₈O₂S
• Molecular Weight: 156.2
• Product Categories: Heterocyclic Compounds
• Mol File: 5928-51-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 46-49 °C(lit.)
• Boiling Point: 250.45°C (rough estimate)
• Flash Point: >230 °F
• Appearance: White to beige/Crystals or Needles
• Density: 1.2474 (rough estimate)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.5460 (estimate)
• Storage Temp.: 2-8°C
• PKA: 4.47±0.10(Predicted)
• CAS DataBase Reference: 3-(2-THIENYL)PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-THIENYL)PROPIONIC ACID(5928-51-8)
• EPA Substance Registry System: 3-(2-THIENYL)PROPIONIC ACID(5928-51-8)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 5928-51-8(Hazardous Substances Data)

Usage

Description

3-(2-THIENYL)PROPIONIC ACID, also known as 3-(Thiophen-2-yl)propionic Acid, is an organic compound that serves as an intermediate in the synthesis of various pharmaceuticals. It is characterized by its white to beige crystalline or needle-like appearance.

Uses

Used in Pharmaceutical Industry:
3-(2-THIENYL)PROPIONIC ACID is used as an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists. It is utilized for the development of antihypertensive agents, specifically targeting the treatment of high blood pressure.
In the synthesis of Eprosartan, 3-(2-THIENYL)PROPIONIC ACID plays a crucial role in creating a compound that can effectively block the action of angiotensin II, a potent vasoconstrictor. By inhibiting the effects of angiotensin II, Eprosartan helps to lower blood pressure and provide relief from hypertension-related symptoms.

InChI:InChI=1/C7H5BrN2/c8-6-2-1-5-4-9-10-7(5)3-6/h1-4H,(H,9,10)

Upstream product

• 19498-72-7 3-thiophen-2-yl-propan-1-ol 

Downstream Products

• 16862-05-8 methyl 3-(2-thienyl)propanoate 
• 906541-07-9 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N'-[[3-(2-thienyl)propanoyl]oxy]-1H-pyrazole-3-carboximidamide 
• 311803-78-8 4-(thiophen-2-yl)-3-(toluene-4-sulfonyloxymethyl)butyric acid tert-butyl ester 
• 225378-33-6 (S)-N-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-3-thiophen-2-ylmethyl-succinamic acid 
• 225377-83-3 N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-4-(1,1-dimethylethoxy)-4-oxo-2(S)-(2-thienylmethyl)butanamide 
• 71351-13-8 2-[2-(5-Methyl-1H-imidazol-4-ylmethylsulfanyl)-ethylamino]-5-thiophen-2-ylmethyl-1H-pyrimidin-4-one; hydrobromide 
• 96103-43-4 8-Benzyl-7-oxo-4,5,7,8,9,10-hexahydro-10aH-thieno<3',2':3,4>pyrido<1,2-c>pyrimidine 
• 71777-98-5 1-phenyl-3-(thiophen-2-yl) propan-1-one 
• 30433-91-1 [2-(2-thyenyl)ethyl]amine 
• 19498-72-7 3-thiophen-2-yl-propan-1-ol 
• 1309207-69-9 1-benzhydryl-3-(3-(thiophen-2-yl)propoxy)azetidine 
• 1313027-25-6 (E)-N,N-diallyl-2-(2-(3,4-dimethylphenyl)hydrazono)-4-(thiophen-2-yl)butanamide 

Relevant articles and documents

Metal-Free Chemoselective Oxidative Dehomologation or Direct Oxidation of Alcohols: Implication for Biomass Conversion

A transition metal-free, chemoselective reaction was performed using the sodium tert-butoxide-oxygen (NaOtBu-O2) system, resulting in either oxidative dehomologation or direct oxidation of alcohols. In particular, the newly developed protocol may be used to predict the major product formed, which depends on alkyl chain length of the alcohols and reaction conditions. The rational mechanism of this transformation was also demonstrated by performing an 18O isotopic labelling experiment. This protocol presents a straightforward method for biomass conversion of a lignin model compound to phenol and benzoic acid.