593-92-0Relevant articles and documents
Catalytic Enantioselective Synthesis of 1,4-Keto-Alkenylboronate Esters and 1,4-Dicarbonyls
Liang, Michael Z.,Meek, Simon J.
supporting information, p. 14234 - 14239 (2019/08/30)
A catalytic enantioselective method for the synthesis of 1,4-keto-alkenylboronate esters by a rhodium-catalyzed conjugate addition pathway is disclosed. A variety of novel, bench-stable alkenyl gem-diboronate esters are synthesized. These easily accessible reagents react smoothly with a collection of cyclic α,β-unsaturated ketones, generating a new C?C bond and stereocenter. Products are isolated in up to 99 % yield with greater than 20:1 E/Z and greater than 99:1 e.r. Mechanistic studies show the site-selectivity of transmetalation and reactivity is ligand dependent. The utility of the approach is highlighted by gram-scale synthesis of enantioenriched cyclic 1,4-diketones, and stereoselective transformations of the products by hydrogenation, allylation, and isomerization.
METHOD FOR PRODUCING 1,1-DIBROMO-1-FLUOROETHANE
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Paragraph 0087, (2016/08/29)
An object of the present invention is to provide a production method that makes it possible to produce 1,1-dibromo-1-fluoroethane easily and sustainably. The present invention provides a method for producing 1,1-dibromo-1-fluoroethane, the method comprising step A of reacting 1,1-dibromoethylene with hydrogen fluoride to obtain 1,1-dibromo-1-fluoroethane.
METHOD FOR MANUFACTURING 1,1,2-TRIBROMOETHANE
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Paragraph 0071, (2016/10/07)
PROBLEM TO BE SOLVED: To provide a method for manufacturing 1,1,2-tribromoethane at low cost and high yield. SOLUTION: There is provided a method for manufacturing 1,1,2-tribromoethane, including a process A of brominating 1,1,2-trihaloethane represented by the formula (1), where X1, X2 and X3 represent a chlorine atom or a bromine atom, however at least one of X1, X2 and X3 is a chlorine atom, to obtain 1,1,2-tribromoethane. COPYRIGHT: (C)2016,JPO&INPIT