593268-10-1

Basic information

• Product Name: Carbamic acid, [3-[[5-(2-methylbenzoyl)-2-thiazolyl]amino]propyl]-, 1,1-dimethylethyl ester
• CAS NO: 593268-10-1
• Molecular Formula: C19H25N3O3S
• Molecular Weight: 375.492
• Mol File: 593268-10-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [3-[[5-(2-methylbenzoyl)-2-thiazolyl]amino]propyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [3-[[5-(2-methylbenzoyl)-2-thiazolyl]amino]propyl]-, 1,1-dimethylethyl ester(593268-10-1)
• EPA Substance Registry System: Carbamic acid, [3-[[5-(2-methylbenzoyl)-2-thiazolyl]amino]propyl]-, 1,1-dimethylethyl ester(593268-10-1)

Safety Data

• Hazardous Substances Data: 593268-10-1(Hazardous Substances Data)

Upstream product

• 51012-65-8 2-bromo-1-o-tolylethanone 
• 593270-19-0 [3-(3-dimethylaminomethylene-thioureido)-propyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Isomeric thiazole derivatives as ligands for the neuropeptide Y5 receptor

Sets of isomeric thiazole derivatives 1 and 2 have been synthesised in a parallel iterative solution-phase synthesis approach guided by the SAR analysis derived from biological results and computer-aided design and analysis. This synergistic and streamlined working procedure led to highly active isomeric NPY5 receptor ligands. However, a 10-fold difference at least in their respective binding affinities was consistently found for all isomeric pairs 1 and 2. The analysis of conformational differences due to heteroatom interactions in 1 and 2 revealed a favourable C=O...S interaction in 1, whereas thiazoles 2 showed a repulsive C=O...N interaction.