5933-32-4

Basic information

• Product Name: 4-BROMOBENZHYDRAZIDE
• Synonyms: 4-BROMOBENZOYLHYDRAZINE;4-BROMO-BENZOIC ACID HYDRAZIDE;4-BROMOBENZOIC HYDRAZIDE;4-BROMOBENZHYDRAZIDE;4-BROMOBENZOHYDRAZIDE;Benzoic acid, 4-bromo-, hydrazide;Benzoic acid, p-bromo-, hydrazide;p-bromo-benzoicacihydrazide
• CAS NO: 5933-32-4
• Molecular Formula: C₇H₇BrN₂O
• Molecular Weight: 215.05
• EINECS: 227-681-9
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Bromine Compounds;Carbonyl Compounds;Hydrazides;Organic Building Blocks
• Mol File: 5933-32-4.mol
• Article Data: 119

Chemical Properties

• Melting Point: 167-169°C
• Boiling Point: 353.2 °C at 760 mmHg
• Flash Point: 167.4 °C
• Appearance: Light beige/Powder
• Density: 1.615 g/cm³
• Vapor Pressure: 1.34E-05mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 12.09±0.10(Predicted)
• Water Solubility: Soluble in hot methanol (almost transparency). Slightly soluble in water.
• BRN: 777006
• CAS DataBase Reference: 4-BROMOBENZHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOBENZHYDRAZIDE(5933-32-4)
• EPA Substance Registry System: 4-BROMOBENZHYDRAZIDE(5933-32-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39
• WGK Germany: 3
• RTECS: DG4449250
• Hazardous Substances Data: 5933-32-4(Hazardous Substances Data)

Usage

Description

4-BROMOBENZHYDRAZIDE is a light beige powder that serves as an essential intermediate in the synthesis of various organic compounds and pharmaceuticals. It is a chemical compound with the molecular formula C7H6BrN3 and is known for its significant role in the preparation of different organic molecules.

Uses

Used in Pharmaceutical Industry:
4-BROMOBENZHYDRAZIDE is used as a key intermediate for the synthesis of various pharmaceutical compounds. It plays a crucial role in the preparation of 2-[1-oxo-3-(4-bromophenyl)-2-propenyl]hydrazide-4-bromobenzoic acid, which is an important molecule in the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 4-BROMOBENZHYDRAZIDE is used as a starting material for the synthesis of various organic compounds, including 2,2?-[1,4-phenylenebis(1-oxo-2-propene-3,1-diyl)]dihydrazide-p-bromobenzoic acid and substituted period[1,2-a]pyrimidine-2,4(3H)-diones (PPMDO). These synthesized compounds can be further utilized in the development of new drugs, materials, or other applications in the chemical industry.
Used in Material Science:
4-BROMOBENZHYDRAZIDE can also be employed in the development of new materials with specific properties, such as optical, electronic, or magnetic characteristics. The synthesized compounds from this intermediate can be used in the creation of advanced materials for various applications, including sensors, displays, and energy storage devices.

InChI:InChI=1/C7H7BrN2O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,9H2,(H,10,11)

Upstream product

• 5798-75-4 Ethyl 4-bromobenzoate 
• 1633-33-6 4-bromobenzoic anhydride 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 5798-76-5 phenyl 4-bromobenzoate 
• 586-76-5 4-Bromobenzoic acid 
• 586-75-4 4-chlorobenzoyl chloride 
• 7803-57-8 hydrazine hydrate 
• 82892-00-0 N-(4-bromobenzoyl)imidazole 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 93444-96-3 furfural-(4-bromo-benzoylhydrazone) 
• 74038-71-4 N’-acetyl-4-bromobenzohydrazide 
• 76328-73-9 3-(4-bromo-benzoylhydrazono)-butyric acid ethyl ester 
• 82973-11-3 benzaldehyde-4-bromobenzoylhydrazone 
• 41420-90-0 2-(4-bromophenyl)-1,3,4-oxadiazole 
• 103038-37-5 N-(1-methylethylidene)-4-bromobenzohydrazide 
• 20640-39-5 D-Arabino-hexosulose-bis-(4-brom-benzoyl-hydrazon) 
• 70092-95-4 4-Bromo-benzoic acid [3-hydroxy-5,5-dimethyl-cyclohex-2-en-(Z)-ylidene]-hydrazide 
• 21510-43-0 2-(4-bromophenyl)-5-phenyl-1,3,4-oxadiazole 
• 51707-12-1 3-[(4-bromo-benzoylhydrazono)-methyl]-rifamycin 
• 132145-05-2 p-bromobenzoic acid β-benzylhydrazide 
• 88238-17-9 1-(p-bromobenzoyl)-2-D-gluconylhydrazine 
• 1122-91-4 4-bromo-benzaldehyde 
• 827579-61-3 C₁₅H₁₄BrN₃OS 

Relevant articles and documents

Pleuromutilin derivative with 1, 3, 4-oxadiazole side chain and preparation and application thereof

The invention belongs to the field of medicinal chemistry, and particularly relates to a pleuromutilin derivative with a 1, 3, 4-oxadiazole side chain and preparation and application thereof The pleuromutilin derivative with the 1, 3, 4-oxadiazole side chain is a compound shown in a formula 2 or a pharmaceutically acceptable salt thereof, and a solvent compound, an enantiomer, a diastereoisomer and a tautomer of the compound shown in the formula 2 or the pharmaceutically acceptable salt thereof or a mixture of the solvent compound, the enantiomer, the diastereoisomer and the tautomer in any proportion, including a racemic mixture. The pleuromutilin derivative has good antibacterial activity, is especially suitable for being used as a novel antibacterial agent for systemic system infection of animals or human beings, and has good water solubility.

Iron-catalyzed oxidative amidation of acylhydrazines with amines

A new approach for amide bond formation via a mild and efficient Iron-catalyzed cross-coupling reaction of acylhydrazines and amines using TBHP as oxidant is described. This protocol is compatible with a wide range of amines and acylhydrazines. In addition, the synthetic application of the reaction is presented.

Design, synthesis and characterization of π-conjugated 2,5-diphenylsubstituted-1,3,4-oxadiazole-based D-π-A-π’-D′ form of efficient deep blue functional materials: Photophysical properties and fluorescence “Turn-off” chemsensors approach

This paper primarily deals with the design and synthesis of three novel conjugated organic molecules containing 1,3,4-oxadiazole unit (abbreviated as CHEM-6(a-c)) with Donor-π-Acceptor-π’-Donor’ structures by utilizing palladium catalyzed Suzuki cross coupling reaction. Molecular structures of these compounds were characterized by using various spectroscopic and analytical techniques namely 1H NMR, 13C NMR, FT-IR, GC–MS and elemental analysis. Optical properties of these compounds have been investigated by using UV–visible absorption and fluorescence spectroscopy. Also, the PL investigations on solid state samples (as thin films) were carried out. Furthermore, solvatochromism and Density Functional Theory (DFT) computations are studied in detail. The experimentally measured optical band gap (Egopt) values of compounds CHEM-6a, CHEM-6b and CHEM-6c were determined to be 3.11, 3.03 and 2.70 eV, respectively. The DSC and TGA results revealed that the compounds exhibit good thermal stabilities. Current results indicate that the compounds CHEM-6(a-c) are promising candidates and could play an important role in the field of optoelectronic devices and possibly find potential applications in development of OLEDs. In addition, the compounds CHEM-6(a-c) showed an interesting property of chemical sensing for Hg(II) ion which can be clearly observed by naked eyes from the changes in solution color and fluorescence (under UV excitation).