594-39-8

Basic information

• Product Name: TERT-AMYLAMINE
• Synonyms: 2-methyl-2-butanamine;alpha,alpha-Dimethylpropylamine;amineamyliquetertiaire;tert-C5H11NH2;1,1-DIMETHYLPROPYLAMINE;2-METHYL-2-BUTYLAMINE;tert-Pentylamine,98%;1,1-Dimethylpropylamine, tert-Pentylamine
• CAS NO: 594-39-8
• Molecular Formula: C₅H₁₃N
• Molecular Weight: 87.16
• EINECS: 209-839-9
• Mol File: 594-39-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: -105°C
• Boiling Point: 77 °C(lit.)
• Flash Point: 30 °F
• Appearance: Clear yellow to brownish/Liquid
• Density: 0.746 g/mL at 25 °C(lit.)
• Vapor Pressure: 98.5mmHg at 25°C
• Refractive Index: n20/D 1.3996(lit.)
• Storage Temp.: Flammables area
• PKA: 10.85(at 19℃)
• Water Solubility: Soluble in water
• CAS DataBase Reference: TERT-AMYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-AMYLAMINE(594-39-8)
• EPA Substance Registry System: TERT-AMYLAMINE(594-39-8)

Safety Data

• Hazard Codes: F,C,T
• Statements: 11-34-25
• Safety Statements: 16-26-27-36/37/39-45
• RIDADR: UN 1106 3/PG 2
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 594-39-8(Hazardous Substances Data)

Usage

Description

TERT-AMYLAMINE is a chemical compound that is used as a substitute for the t-butylamino substituent in cyanobenzylamine derivatives. It is known for its unique properties and potential applications in various industries.

Uses

Used in Chemical Synthesis:
TERT-AMYLAMINE is used as a substitute for the t-butylamino substituent in cyanobenzylamine derivatives, which are important intermediates in the synthesis of various pharmaceuticals and agrochemicals. Its use as a substitute allows for the development of new compounds with improved properties and potential applications.
Used in Pharmaceutical Industry:
TERT-AMYLAMINE is used as a building block in the synthesis of various pharmaceutical compounds. Its unique properties and reactivity make it a valuable component in the development of new drugs with improved efficacy and safety profiles.
Used in Agrochemical Industry:
TERT-AMYLAMINE is also used in the synthesis of agrochemicals, such as pesticides and herbicides. Its use as a substitute for the t-butylamino substituent in cyanobenzylamine derivatives allows for the development of new agrochemicals with enhanced performance and reduced environmental impact.

InChI:InChI=1/C5H13N/c1-4-5(2,3)6/h4,6H2,1-3H3/p+1

Upstream product

• 67-62-9 O-Methylhydroxylamin 
• 28276-08-6 1,1-dimethylpropylmagnesium chloride 
• 75-85-4 tert-Amyl alcohol 
• 143-33-9 sodium cyanide 
• 151-50-8 potassium cyanide 
• 598-75-4 3-methyl-2-butanol 
• 594-38-7 2-iodo-2-methylbutane 
• 3315-16-0 silver cyanate 
• 2978-60-1 1,1-dimethylprop-2-en-1-yl-amine 
• 926-04-5 3,3-dimethylbutanamide 
• 625-15-0 tert-amylurea 
• 19656-71-4 N,N'-di-tert-pentyl-urea 
• 563-46-2 2-Methyl-1-butene 
• 506-77-4 cyanogen chloride 

Downstream Products

• 110799-28-5 benzothiazole-2-sulfenic acid tert-pentylamide 
• 34946-78-6 2-methyl-2-nitrosobutane 
• 597-97-7 1,1-dimethylpropyl isothiocyanate 
• 595-42-6 2-methyl-2-nitrobutane 
• 91907-80-1 N-tert-pentyl-N'-phenyl-urea 
• 14294-25-8 N-tert-pentyl-N'-phenyl-thiourea 
• 2978-40-7 3-tert.-Amylamino-3-methyl-1-butin 
• 71757-44-3 1-(1,1-Dimethyl-propyl)-3-(2,4,6-triethyl-cyclohexyl)-thiourea 
• 66608-95-5 N-(2-Methyl-6-aethyl-phenyl)-N'-tert.-pentyl-thioharnstoff 
• 66609-00-5 N-(2,4-dimethyl-6-ethyl-phenyl)-N'-tert.-pentyl-thiourea 
• 67330-89-6 1-(2,6-Diethyl-3,4-dimethyl-phenyl)-3-(1,1-dimethyl-propyl)-thiourea 
• 66608-82-0 N-(2.6-Di-sec.-butyl-phenyl)-N'-tert.-pentyl-thioharnstoff 
• 66608-91-1 N-(2.6-Diaethyl-phenyl)-N'-tert.-pentyl-thioharnstoff 
• 67330-81-8 1-(2,6-Diethyl-3-methyl-phenyl)-3-(1,1-dimethyl-propyl)-thiourea 

Relevant articles and documents

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cis-2,5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: Synthesis and in vitro, in vivo, and x-ray crystallographic characterization

Inhibitors of the glucagon-like peptide-1 (GLP-1) degrading enzyme dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2 diabetes in animal models and in human subjects. A novel series of cis-2,5-dicyanopyrrolidine α-amino amides were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-IV) for the treatment of type 2 diabetes. 1-({[1-(Hydroxymethyl)cyclopentyl]amino}-acetyl)pyrrolidine-2,5-cis- dicarbonitrile (1c) is an achiral, slow-binding (time-dependent) inhibitor of DPP-IV that is selective for DPP-IV over other DPP isozymes and proline specific serine proteases, and which has oral bioavailability in preclinical species and in vivo efficacy in animal models. The mode of binding of the cis-2,5-dicyanopyrrolidine moiety was determined by X-ray crystallography. The hydrochloride salt of 1c was further profiled for development as a potential new treatment for type 2 diabetes.

Use of (S)-(Trifloxymethyl)oxirane in the synthesis of a chiral β-adrenoceptor antagonist, (R)- and (S)-9-[[3-(tert-butylamino)-2-hydroxypropyl]oximino]fluorene

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