59403-74-6Relevant articles and documents
One-Pot Four-Component Assembling for Selenoureas
Li, Lai,Wu, Jiaqi,Wei, Linsha,Lu, Jianmei,Jiang, Xuefeng
, p. 446 - 454 (2020/12/23)
An efficient and practical method for the straightforward construction of unsymmetrical selenoureas and cycloselenoureas via the combination of selenium powder, chloroform, and two different amines was comprehensively achieved in one-pot with only the assistance of a base under mild conditions. Thirty-three new structures of unsymmetrical selenoureas including three chiral examples and eight cycloselenoureas were achieved. 1,1-Dimethyl-3-phenylselenourea II, which shows good fungicidal activity, was practically synthesized through this protocol in gram-scale. Isoselenocyanate was further confirmed as a key intermediate by control experiment.