59410-89-8

Basic information

• Product Name: METHYL D-4-CHLOROPHENYLGLYCINATE HCL
• Synonyms: METHYL D-4-CHLOROPHENYLGLYCINATE HCL;(R)-Methyl 2-amino-2-(4-chlorophenyl)acetate HCl;-Methyl 2-amino-2-(4-chlorophenyl);R-4-Chlorophenylglycine methyl ester hydrochloride
• CAS NO: 59410-89-8
• Molecular Formula: C9H10 Cl N O2 . Cl H
• Molecular Weight: 0
• Mol File: 59410-89-8.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL D-4-CHLOROPHENYLGLYCINATE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL D-4-CHLOROPHENYLGLYCINATE HCL(59410-89-8)
• EPA Substance Registry System: METHYL D-4-CHLOROPHENYLGLYCINATE HCL(59410-89-8)

Safety Data

• Hazardous Substances Data: 59410-89-8(Hazardous Substances Data)

Usage

General Description

Methyl D-4-chlorophenylglycinate HCl, also known as glyphosate, is a widely used herbicide that inhibits the activity of a plant enzyme involved in the synthesis of essential amino acids. It is effective in controlling a broad spectrum of weeds and is commonly used in agricultural and horticultural practices. However, it has been the subject of controversy due to its potential environmental and health risks. Research has linked glyphosate to negative effects on aquatic ecosystems and harm to non-target plants and animals, as well as potential carcinogenic and endocrine-disrupting properties. Regulatory agencies and scientific organizations continue to evaluate the safety and sustainability of glyphosate use in light of these concerns.

Upstream product

• 67-56-1 methanol 
• 6212-33-5 2-(4-Chlorophenyl)glycine 
• 104-88-1 4-chlorobenzaldehyde 
• 890656-91-4 (R)-(4-Chloro-phenyl)-((R)-2-methyl-propane-2-sulfinylamino)-acetic acid methyl ester 
• 1679-18-1 4-Chlorophenylboronic acid 
• 67336-19-0 (S)-2-amino-2-(4-chlorophenyl)acetic acid 

Downstream Products

• 127022-84-8 DL-2-(4-Chlorphenyl)-glycinoctylamid 
• 80589-53-3 (4-Chloro-phenyl)-(4-cyanomethyl-benzoylamino)-acetic acid methyl ester 
• 131786-21-5 trimethyl 2-(4'-chlorophenyl)-5-(4'-methoxyphenyl)-3-pyrroline-2,3,4-tricarboxylate 
• 1345870-51-0 methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate 
• 1384246-22-3 C₂₃H₂₇ClN₄O₅ 
• 1620738-98-8 (4-chlorophenyl)-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester 
• 1356585-06-2 4-(4-chlorophenyl)-2-(4-methoxyphenyl)oxazol-5(4H)-one 
• 923975-81-9 3-(4-chlorophenyl)-1,4-diazaspiro[4.5]dec-3-en-2-one 
• 923975-86-4 [3-(4-chlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl]acetyl chloride 
• 923975-85-3 [3-(4-chlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl]acetic acid 
• 923975-84-2 ethyl [3-(4-chlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl]acetate 

Relevant articles and documents

CHEMOSELECTIVE METHYLENE HYDROXYLATION IN AROMATIC MOLECULES

A chemoselective and reactive Mn(CF3-PDP) catalyst system that enables for the first time the strategic advantages of late-stage aliphatic C—H hydroxylation to be leveraged in aromatic compounds. This discovery will benefit small molecule therapeutics by enabling the rapid diversification of aromatic drugs and natural products and identification of their metabolites.

Ru-catalyzed C[sbnd]H functionalization of phenylglycine derivatives: Synthesis of isoquinoline-1-carboxylates and isoindoline-1-carboxylates

The reaction of N-unprotected methylesters of phenylglycine derivatives (1a–1f) with electron-rich internal alkynes (2a–2e), catalyzed by [Ru(cymene)Cl2]2 (10%), gives the corresponding 3,4-disubstituted isoquinoline-1-carboxylates 3 through C[sbnd]H/N[sbnd]H oxidative coupling. The C[sbnd]H bond activation step is assisted by carboxylates, and N-fluoro-2,4,6-trimethylpyridinium triflate works as the terminal oxidant. The process shows a remarkable tolerance to the presence of diverse electron-releasing and electron-attracting functional groups at the phenyl ring of the amino acid. In addition, the reaction of phenylglycine derivatives (1a–1f) with methyl acrylate (4a) catalyzed by [Ru(cymene)Cl2]2 (10%) under the same experimental conditions, gives the corresponding 3,N-disubstituted isoindoline-1-carboxylates 5 through C[sbnd]H/N[sbnd]H coupling. Isoindolines 5 are obtained as a mixture of diastereoisomers, with moderate to high values of diastereomeric excess (up to 80%).

GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

Compounds of Formula (I) or a salt thereof are provided: wherein R6, R7, R8, R9, X, Ar, n, and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for