59664-42-5

Basic information

• Product Name: 2,4-BIS(TRIFLUOROMETHYL)BENZALDEHYDE
• Synonyms: 2,4-Bis(trifluoromethyl)benzaldehyde98%;2,4-Bis(trifluoromethyl;2,4-BIS(TRIFLUOROMETHYL)BENZALDEHYDE;2,4-DI(TRIFLUOROMETHYL)BENZALDEHYDE;2,4-Bis(trifluoromethyl)benzaldehyde 98%
• CAS NO: 59664-42-5
• Molecular Formula: C₉H₄F₆O
• Molecular Weight: 242.12
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzene series;Benzaldehyde;Aldehydes;C9;Carbonyl Compounds;Fluorine series
• Mol File: 59664-42-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 172 °C(lit.)
• Flash Point: 155 °F
• Appearance: clear, colorless to pale yellow liquid
• Density: 1.48 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.409mmHg at 25°C
• Refractive Index: n20/D 1.422(lit.)
• Storage Temp.: 0-10°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2,4-BIS(TRIFLUOROMETHYL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-BIS(TRIFLUOROMETHYL)BENZALDEHYDE(59664-42-5)
• EPA Substance Registry System: 2,4-BIS(TRIFLUOROMETHYL)BENZALDEHYDE(59664-42-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 59664-42-5(Hazardous Substances Data)

Usage

General Description

2,4-Bis(trifluoromethyl)benzaldehyde is a chemical compound with the formula C9H4F6O. It is a white to light yellow crystalline solid that is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used as an intermediate in the production of dyes, fragrances, and other specialty chemicals. 2,4-Bis(trifluoromethyl)benzaldehyde has a strong aromatic odor and is insoluble in water but soluble in organic solvents. It is important to handle this chemical with care and use appropriate safety precautions due to its potential health hazards and reactivity.

InChI:InChI=1/C6H2Br3F9/c7-1-2(8,9)3(10,11)4(12,13)5(14,15)6(16,17)18/h1H2

Upstream product

• 120530-42-9 ethyl 3,4,5-trichlorobenzoate 
• 768-66-1 2,2,6,6-tetramethyl-piperidine 
• 402-31-3 1,3-bis(trifluoromethyl)benzene 
• 143158-15-0 [2,4-bis(trifluoromethyl)phenyl]methanol 
• 201230-82-2 carbon monoxide 

Downstream Products

• 262268-46-2 (E)-3-(2,4-bis-trifluoromethylphenyl)propenal 
• 848863-56-9 (E,E)-1,4-di(o,p-bis(trifluoromethyl)phenyl)-1,3-butadiene 
• 781659-42-5 N-2,4-bis(trifluoromethyl)benzyl-3-hydroxypropylamine 
• 858938-91-7 2,4-bis(trifluoromethyl)benzaldehyde oxime 
• 869318-86-5 N-{(1E)-[2,4-bis(trifluoromethyl)phenyl]methylene}-2-methylpropane-2-sulfiamide 
• 1269259-72-4 (2E,4E,6E,8E)-9-(2,4-bis(trifluoromethyl)phenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid 
• 143158-15-0 [2,4-bis(trifluoromethyl)phenyl]methanol 
• 1276115-57-1 5-(2,4-bis-trifluoromethylphenyl)-3-hydroxy-1-(2-hydroxypropyl)-4-(4-methylbenzoyl)-1,5-dihydropyrrol-2-one 

Relevant articles and documents

An aerobic oxidation of alcohols into carbonyl synthons using bipyridyl-cinchona based palladium catalyst

We have reported an aerobic oxidation of primary and secondary alcohols to respective aldehydes and ketones using a bipyridyl-cinchona alkaloid based palladium catalytic system (PdAc-5) using oxygen at moderate pressure. ThePdAc-5catalyst was analysed using SEM, EDAX, and XPS analysis. The above catalytic system is used in experiments for different oxidation systems which include different solvents, additives, and bases which are cheap, robust, non-toxic, and commercially available on the industrial bench. The obtained products are quite appreciable in both yield and selectivity (70-85%). In addition, numerous important studies, such as comparisons with various commercial catalysts, solvent systems, mixture of solvents, and catalyst mole%, were conducted usingPdAc-5. The synthetic strategy of oxidation of alcohol into carbonyl compounds was well established and all the products were analysed using1H NMR,13CNMR and GC-mass analyses.

Process for producing trifluoromethylbenzylamines

The present invention relates to a process for producing a trifluoromethylbenzylamine represented by the general formula (1). This process includes the step of reducing an oxime represented by the general formula (2), where R1represents hydrogen atom, a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, or trifluoromethyl group, where R1is defined as above, and R2represents hydrogen atom, an alkyl group or an aralkyl group. With this process, the trifluoromethylbenzylamine can be produced with high selectivity.

Process for lithiation of 1,3-bis(trifluoromethyl)benzene

A novel process for the lithiation of 1,3-bis(trifluoro-methyl)benzene in a solvent is described, said process comprising carrying out the lithiation with the lithium salt of an amine of the general formula wherein R1 and R2 are secondary or tertiary lower alkyl or secondary or tertiary lower alkyl substituted by a lower alkyl or lower cycloalkyl or lower cycloaklyl substituted by a lower alkyl, or R1 and R2 taken together form a C6-14 -alkylene group in which the two carbon atoms linked with the nitrogen atom are secondary or tertiary and are separated from each other by 2 to 4 carbon atoms. The solution of the lithiated 1,3-bis(trifluoromethyl)-benzene obtained can be reacted with an electrophile which is suitable for the substitution of lethiated benzene derivatives, whereby a compound of the formula STR1 wherein R3 signifies the residue of an electrophile which is suitable for the substitution of lithiated benzene derivatives, is obtained.