59667-21-9

Basic information

• Product Name: p-Chloro-β-methylphenethyl alcohol
• Synonyms: p-Chloro-β-methylphenethyl alcohol
• CAS NO: 59667-21-9
• Molecular Weight: 170.639
• Mol File: 59667-21-9.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: p-Chloro-β-methylphenethyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: p-Chloro-β-methylphenethyl alcohol(59667-21-9)
• EPA Substance Registry System: p-Chloro-β-methylphenethyl alcohol(59667-21-9)

Safety Data

• Hazardous Substances Data: 59667-21-9(Hazardous Substances Data)

Upstream product

• 1712-70-5 1-chloro-4-(1-methylethenyl)-benzene 
• 1875-88-3 2-(4-Chlorophenyl)ethanol 
• 201230-82-2 carbon monoxide 
• 67-56-1 methanol 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 50415-70-8 methyl 2-(p-chlorophenyl)propionate 
• 1669-70-1 p-chloro-α-methylstyrene oxide 
• 1073-67-2 4-vinylbenzyl chloride 
• 938-95-4 2-(4-Chloro-phenyl)-propionic acid 
• 637-87-6 1-Chloro-4-iodobenzene 
• 107-18-6 allyl alcohol 
• 1989-25-9 4-chlorocumyl alcohol 
• 106-39-8 bromochlorobenzene 
• 2184-88-5 2-(4-chlorophenyl)propionitrile 

Downstream Products

• 286964-62-3 2-(4-chlorophenyl)propanal 
• 99-91-2 para-chloroacetophenone 

Relevant articles and documents

Iridium-Catalyzed Domino Hydroformylation/Hydrogenation of Olefins to Alcohols: Synergy of Two Ligands

A novel one-pot iridium-catalyzed domino hydroxymethylation of olefins, which relies on using two different ligands at the same time, is reported. DFT computation reveals different activities for the individual hydroformylation and hydrogenation steps in the presence of mono- and bidentate ligands. Whereas bidentate ligands have higher hydrogenation activity, monodentate ligands show higher hydroformylation activity. Accordingly, a catalyst system is introduced that uses dual ligands in the whole domino process. Control experiments show that the overall selectivity is kinetically controlled. Both computation and experiment explain the function of the two optimized ligands during the domino process.

Highly efficient NHC-iridium-catalyzed β-methylation of alcohols with methanol at low catalyst loadings

The methylation of alcohols is of great importance since a broad number of bioactive and pharmaceutical alcohols contain methyl groups. Here, a highly efficient β-methylation of primary and secondary alcohols with methanol has been achieved by using bis-N-heterocyclic carbene iridium (bis-NHC-Ir) complexes. Broad substrate scope and up to quantitative yields were achieved at low catalyst loadings with only hydrogen and water as by-products. The protocol was readily extended to the β-alkylation of alcohols with several primary alcohols. Control experiments, along with DFT calculations and crystallographic studies, revealed that the ligand effect is critical to their excellent catalytic performance, shedding light on more challenging Guerbet reactions with simple alcohols. [Figure not available: see fulltext.].

Manganese(I)-Catalyzed β-Methylation of Alcohols Using Methanol as C1 Source

Highly selective β-methylation of alcohols was achieved using an earth-abundant first row transition metal in the air stable molecular manganese complex [Mn(CO)2Br[HN(C2H4PiPr2)2]] 1 ([HN(C2H4PiPr2)2]=MACHO-iPr). The reaction requires only low loadings of 1 (0.5 mol %), methanolate as base and MeOH as methylation reagent as well as solvent. Various alcohols were β-methylated with very good selectivity (>99 %) and excellent yield (up to 94 %). Biomass derived aliphatic alcohols and diols were also selectively methylated on the β-position, opening a pathway to “biohybrid” molecules constructed entirely from non-fossil carbon. Mechanistic studies indicate that the reaction proceeds through a borrowing hydrogen pathway involving metal–ligand cooperation at the Mn-pincer complex. This transformation provides a convenient, economical, and environmentally benign pathway for the selective C?C bond formation with potential applications for the preparation of advanced biofuels, fine chemicals, and biologically active molecules.