59702-08-8

Basic information

• Product Name: 1-ETHYLPIPERAZIN-2-ONE
• Synonyms: 1-Ethyl-piperazin-2-one ,98%;1-Ethyl-piperazin-2-one ,95%;1-ethylpiperazin-2-one(SALTDATA: 1.05HCl 0.2H2O);1-ethylpiperazin-2-one 1.05HCl 0.2H2O;1-ethylpiperazin-2-one hydrochloride;4-Ethyl-3-oxopiperazine;1-Ethyl-2-piperazinone
• CAS NO: 59702-08-8
• Molecular Formula: C₆H₁₂N₂O
• Molecular Weight: 128.1723
• Mol File: 59702-08-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 255℃
• Flash Point: 108℃
• Appearance: /
• Density: 1.004
• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.458
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 7.82±0.20(Predicted)
• CAS DataBase Reference: 1-ETHYLPIPERAZIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHYLPIPERAZIN-2-ONE(59702-08-8)
• EPA Substance Registry System: 1-ETHYLPIPERAZIN-2-ONE(59702-08-8)

Safety Data

• Hazardous Substances Data: 59702-08-8(Hazardous Substances Data)

Usage

Description

1-Ethylpiperazin-2-one, also known as 1-ethyl-2-piperazinone, is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is a heterocyclic compound with a piperazine core, which is a common structural element in many drugs and biologically active molecules. Its chemical properties make it a versatile building block for the development of new therapeutic agents.

Uses

Used in Pharmaceutical Industry:
1-Ethylpiperazin-2-one is used as a synthetic intermediate for the production of piperidine and piperazine derivatives, which are known for their cognitive-enhancing properties. These derivatives have potential applications in the treatment of cognitive disorders and improving cognitive function in various conditions.
In the synthesis of these derivatives, 1-ethylpiperazin-2-one serves as a crucial component, allowing for the development of new drugs with improved efficacy and safety profiles. Its role in the pharmaceutical industry is essential for the advancement of novel therapeutic agents targeting cognitive impairments and related conditions.

InChI:InChI=1/C6H12N2O/c1-2-8-4-3-7-5-6(8)9/h7H,2-5H2,1H3

Upstream product

• 194350-95-3 tert-butyl 4-ethyl-3-oxopiperazine-1-carboxylate 

Downstream Products

• 1240299-78-8 1-ethyl-4-[2-(4-{1-[3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl}phenoxy)ethyl]piperazin-2-one 
• 1255339-65-1 1-ethyl-4-[3-(4-{1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl}phenoxy)propyl]piperazin-2-one 
• 1255339-74-2 1-ethyl-4-[2-(4-{1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl}phenoxy)ethyl]piperazin-2-one 

Relevant articles and documents

PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS

The present disclosure provides compounds of Formula (LA) and/ or pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BTK, and are potentially useful for the treatment of diseases treatable by inhibition of ty r-osine kinases such as cancer, inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and/or pharmaceutically acceptable salts thereof and processes for preparing such compounds and p h ar-maceutically acceptable salts thereof