59721-16-3

Basic information

• Product Name: 4-Hydroxy Benzeneacetic Acid 2-(DiMethylaMino)-2-oxoethyl Ester
• Synonyms: 4-Hydroxy Benzeneacetic Acid 2-(DiMethylaMino)-2-oxoethyl Ester;2-(diMethylaMino)-2-oxoethyl (4-hydroxyphenyl)acetate;2-(diMethylaMino)-2-oxoethyl 2-(4-hydroxyphenyl)acetate;4-Hydroxybenzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester (Camostat mesilate)
• CAS NO: 59721-16-3
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237
• Product Categories: Aromatics;Intermediates;Metabolites & Impurities
• Mol File: 59721-16-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 410.4±30.0 °C(Predicted)
• Appearance: /
• Density: 1.219±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 9.79±0.15(Predicted)
• CAS DataBase Reference: 4-Hydroxy Benzeneacetic Acid 2-(DiMethylaMino)-2-oxoethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy Benzeneacetic Acid 2-(DiMethylaMino)-2-oxoethyl Ester(59721-16-3)
• EPA Substance Registry System: 4-Hydroxy Benzeneacetic Acid 2-(DiMethylaMino)-2-oxoethyl Ester(59721-16-3)

Safety Data

• Hazardous Substances Data: 59721-16-3(Hazardous Substances Data)

Usage

Uses

Impurity of Camostat (C150300).

Upstream product

• 156-38-7 4-hydroxyphenylacetate 
• 5468-77-9 2-bromo-N,N-dimethylethanamide 
• 2675-89-0 2-chloro-N,N-dimethylacetamide 

Downstream Products

• 70884-55-8 5-Nitro-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid 4-dimethylcarbamoylmethoxycarbonylmethyl-phenyl ester 
• 70884-81-0 7-Nitro-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid 4-dimethylcarbamoylmethoxycarbonylmethyl-phenyl ester 
• 59721-29-8 camostat mesylate 
• 59721-28-7 camostat 

Relevant articles and documents

1H-Nuclear magnetic resonance studies on interaction between 4-[4-(N,N-dimethylcarbamoylmethoxycarbonylmethyl) phenoxycarbonylphenyl]guanidinium methanesulfonate and trypsin

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A methanesulfonic acid the card not takes charge of he process for the preparation of intermediates

The invention discloses a preparation method of methanesulfonic acid camostat. The method comprises the following steps: dimethylamine reacts with chloroacetyl chloride to obtain 3-pyrrolidone hydrochloride, a 3-pyrrolidone hydrochloride crude product is added with hydroxyphenylacetic acid and triethylamine to obtain methanesulfonic acid camostat, and a methanesulfonic acid camostat product is prepared from the obtained methanesulfonic acid camostat. The methanesulfonic acid camostat prepared by adopting the method is good in quality, high in yield, less in energy consumption and low in cost, and meanwhile, the preparation method is simple.