59724-43-5

Basic information

• Product Name: 4-BROMO-N-(2-HYDROXYETHYL)BENZENESULPHONAMIDE
• Synonyms: 4-BROMO-N-(2-HYDROXYETHYL)BENZENESULPHONAMIDE;N-(2-HYDROXYETHYL) 4-BROMOBENZENESULFONAMIDE;4-Bromo-N-(2-hydroxyethyl)benzenesulphonamide 98%;4-broMo-N-(2-hydroxyethyl)benzenesulfonaMide;4-Bromo-N-(2-hydroxyethyl)benzenesulphonamide98%
• CAS NO: 59724-43-5
• Molecular Formula: C₈H₁₀BrNO₃S
• Molecular Weight: 280.14
• Product Categories: blocks;Bromides;Sulfonamides
• Mol File: 59724-43-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 76-78
• Boiling Point: 413.5 °C at 760 mmHg
• Flash Point: 203.9 °C
• Appearance: /
• Density: 1.645 g/cm³
• Vapor Pressure: 1.41E-07mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-BROMO-N-(2-HYDROXYETHYL)BENZENESULPHONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-N-(2-HYDROXYETHYL)BENZENESULPHONAMIDE(59724-43-5)
• EPA Substance Registry System: 4-BROMO-N-(2-HYDROXYETHYL)BENZENESULPHONAMIDE(59724-43-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 59724-43-5(Hazardous Substances Data)

Usage

General Description

4-Bromo-N-(2-hydroxyethyl)benzenesulphonamide is a chemical compound also known as 4-Bromo-N-(2-hydroxyethyl)benzenesulfonamide. The molecular formula is C8H10BrNO3S. This is typically found in the form of a solid and is relatively stable under normal conditions. The compound involves a combination of bromine, hydroxyethyl, and benzenesulphonamide groups, which confers certain properties to it. The exact properties and potential applications of the substance can vary, depending on factors such as how it is synthesized and the specific context in which it is used. Its risk and safety assessment hasn't been fully explored yet. Generally, it should be handled with care to avoid potential harm.

InChI:InChI=1/C8H10BrNO3S/c9-7-1-3-8(4-2-7)14(12,13)10-5-6-11/h1-4,10-11H,5-6H2

Upstream product

• 141-43-5 ethanolamine 
• 98-58-8 4-bromobenzenesulfonyl chloride 
• 114396-25-7 2-(phenylthio)ethyl brosylate 
• 74-89-5 methylamine 

Downstream Products

• 1239411-93-8 C₁₈H₁₈N₄O₃S₂ 
• 1380072-17-2 C₂₂H₂₂FNO₆S₂ 
• 1380072-16-1 4'-(benzyloxy)-3'-fluoro-N-(2-hydroxyethyl)-[1,1'-biphenyl]-4-sulfonamide 
• 1451094-54-4 {6-fluoro-4-[4-(2-hydroxy-ethylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid methyl ester 
• 1451094-52-2 {6-chloro-4-[4-(2-hydroxy-ethylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid methyl ester 
• 1451094-51-1 {6-chloro-4-[4-(2-hydroxy-ethylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid 
• 1451094-53-3 {6-fluoro-4-[4-(2-hydroxy-ethylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid 
• 1187448-62-9 4-(2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzenesulfonamide 

Relevant articles and documents

Illuminating a Dark Kinase: Structure-Guided Design, Synthesis, and Evaluation of a Potent Nek1 Inhibitor and Its Effects on the Embryonic Zebrafish Pronephros

NIMA-related kinase 1 (Nek1) has lately garnered attention for its widespread function in ciliogenesis, apoptosis, and the DNA-damage response. Despite its involvement in various diseases and its potential as a cancer drug target, no directed medicinal chemistry efforts toward inhibitors against this dark kinase are published. Here, we report the structure-guided design of a potent small-molecule Nek1 inhibitor, starting from a scaffold identified by kinase cross-screening analysis. Seven lead compounds were identified in silico and evaluated for their inhibitory activity. The top compound, 10f, was further profiled for efficacy, toxicity, and bioavailability in a zebrafish polycystic kidney disease model. Administration of 10f caused the expansion of fluorescence-labeled proximal convoluted tubules, supporting our hypothesis that Nek1-inhibition causes cystic kidneys in zebrafish embryos. Compound 10f displayed insignificant inhibition in 48 of 50 kinases in a selectivity test panel. The findings provide a powerful tool to further elucidate the function and pharmacology of this neglected kinase.

6 - Phenanthridone derivative and its preparation and use (by machine translation)

The invention belongs to the chemical field, and in particular relates to 6 - phenanthridone derivative and its preparation and use. The invention provides a 6 - phenanthridone derivatives, its structural formula as formula I shown. In addition, the inven

TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.