5973-23-9

Basic information

• Product Name: 1,3-dimethyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione(SALTDATA: FREE)
• Synonyms: 1,3-dimethyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione(SALTDATA: FREE);1,3-Dimethyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione;1,3-dimethyl-3,4-dihydro-1,4-benzodiazepine-2,5-dione;1,3-dimethyl-3,4-dihydro-1,4-benzodiazepine-2,5-quinone;3,4-Dihydro-1,3-dimethyl-1H-1,4-benzodiazepine-2,5-dione
• CAS NO: 5973-23-9
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.22518
• Mol File: 5973-23-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.52g/cm³
• Vapor Pressure: 2.03E-11mmHg at 25°C
• Refractive Index: 1.544
• CAS DataBase Reference: 1,3-dimethyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dimethyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione(SALTDATA: FREE)(5973-23-9)
• EPA Substance Registry System: 1,3-dimethyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione(SALTDATA: FREE)(5973-23-9)

Safety Data

• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 5973-23-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 33, p. 1887, 1992 DOI: 10.1016/S0040-4039(00)74168-2

InChI:InChI=1/C11H12N2O2/c1-7-11(15)13(2)9-6-4-3-5-8(9)10(14)12-7/h3-7H,1-2H3,(H,12,14)

Upstream product

• 10328-92-4 N-Methylisatoic anhydride 
• 302-72-7 rac-Ala-OH 
• 141871-02-5 N-Boc-methyl anthranilic acid 

Relevant articles and documents

New routes to 1,4-benzodiazepin-2,5-diones

1,4-benzodiazepin-2,5-diones have been synthesized in good overall yields by two routes, the first one by cyclisation of dipeptides prepared from Boc anthranilic acid and α-amino acid methyl esters, the second one by reaction of N-carboxy α-amino acid anhydrides with Boc anthranilic acid.

A Versatile Synthesis of 3H-1(H),4(H)-Benzodiazepin-2,5-diones

Reaction of isatoic anhydrides (1) and α-amino acids (2) in glacial acetic acid under reflux gave 3H-1(H),4(H)-benzodiazepin-2,5-diones (3) in good yields.These compounds have been characterised by UV, IR, mass, PMR and 13C-NMR spectra.