59752-57-7 Usage
Description
1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, also known as DLPE, is a phospholipid that plays a crucial role in the structure and function of biological membranes. It is a type of phosphatidylethanolamine (PE) with medium-chain lauric acid (12:0) inserted at the sn-1 and sn-2 positions, which contributes to its unique properties and applications.
Uses
Used in Pharmaceutical Applications:
DLPE is used as a component in the preparation of nano-liposomes, which are employed as drug delivery systems. These nano-liposomes enhance the bioavailability, stability, and targeted delivery of various therapeutic agents, improving their efficacy and reducing side effects.
Used in Agricultural Applications:
DLPE is used in the preparation of nano-liposomes, which serve as agricultural auxiliaries in the field of pesticides and fertilizers. These nano-liposomes help improve the delivery, absorption, and effectiveness of agricultural chemicals, leading to better crop protection and yield.
Used in Cosmetic Applications:
DLPE is also utilized in the cosmetic industry as an ingredient in various skincare and hair care products. Its ability to form micelles and liposomes makes it an effective component for enhancing the delivery of active ingredients and improving the overall performance of cosmetic formulations.
Used in Research and Diagnostic Applications:
Due to its structural and functional properties, DLPE is often used in research and diagnostic applications, particularly in the study of membrane biophysics, lipidomics, and the development of artificial cell membranes for various biotechnological applications.
Purification Methods
Recrystallise it from EtOH or tetrahydrofuran. [Bevan & Malkin J Chem Soc 2667 1951, IR: Bellamy & Beecher J Chem Soc 7
Check Digit Verification of cas no
The CAS Registry Mumber 59752-57-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,7,5 and 2 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 59752-57:
(7*5)+(6*9)+(5*7)+(4*5)+(3*2)+(2*5)+(1*7)=167
167 % 10 = 7
So 59752-57-7 is a valid CAS Registry Number.
InChI:InChI=1/C29H58NO8P/c1-3-5-7-9-11-13-15-17-19-21-28(31)35-25-27(26-37-39(33,34)36-24-23-30)38-29(32)22-20-18-16-14-12-10-8-6-4-2/h27H,3-26,30H2,1-2H3,(H,33,34)
59752-57-7Relevant articles and documents
A diacyl phosphatidyl ethanolamine preparation method (by machine translation)
-
Paragraph 0093; 0094; 0095, (2018/11/22)
The invention provides a diacyl phosphatidyl ethanolamine preparation method, comprises the following steps: (1) solvent and organic/inorganic alkali under the action of, the formula I compound and phosphorus reagent undergo the substitution reaction, formula a intermediate 1; (2) in the same reaction system, intermediate 1 of an organic/inorganic the presence of an alkali, with 2 - (N - [...] carbonyl amino) ethanol or N - Boc protection of the ethanolamine undergo the substitution reaction, formula b intermediate 2; (3) in the same reaction system, intermediate 2 under the action of the oxidizing agent in the oxidation reaction, the compound of formula II; (4) the formula II compound in the solvent, under the action of alkali, phospholipid base hydrolysis, formula III compound. The advantage of this invention is characterized in that: the invention only needs two-step synthesis of the target product can be obtained, and the method is easy to control conditions, after treatment is simple, less side reaction, high yield, consistent with the requirements of industrial production. (by machine translation)
