5980-33-6

Basic information

• Product Name: 4-METHYLUMBELLIFERONE SODIUM SALT
• Synonyms: 4-methylumbelliferonesodium;7-hydroxy-4-methyl-2h-1-benzopyran-2-onesodiumsalt;7-hydroxy-4-methyl-2h-1-benzopyran-2-onsodiumsalt;7-hydroxy-4-methylcoumarinsodium;7-hydroxy-4-methyl-coumarisodiumsalt;cantabilinesodium;hymecromonesodium;lm94sodium
• CAS NO: 5980-33-6
• Molecular Formula: C₁₀H₇O₃*Na
• Molecular Weight: 198.15
• EINECS: 227-790-1
• Mol File: 5980-33-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 90-92 °C(lit.)
• Boiling Point: 377.4°C at 760 mmHg
• Flash Point: 174.5°C
• Appearance: yellow/crystalline
• Density: 1.319g/cm³
• Vapor Pressure: 3.11E-06mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 4-METHYLUMBELLIFERONE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLUMBELLIFERONE SODIUM SALT(5980-33-6)
• EPA Substance Registry System: 4-METHYLUMBELLIFERONE SODIUM SALT(5980-33-6)

Safety Data

• Hazard Codes: T+
• Statements: 26/27/28
• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: GN7570000
• Hazardous Substances Data: 5980-33-6(Hazardous Substances Data)

Usage

Description

4-Methylumbelliferone Sodium Salt is a chemical compound derived from the natural product umbelliferone, which is a component of various plants in the Apiaceae family. It is a sodium salt form of 4-methylumbelliferone and is known for its ability to form complexes with certain metals and its inhibitory effects on specific biological processes.

Uses

Used in Pharmaceutical Applications:
4-Methylumbelliferone Sodium Salt is used as a complexing agent for metals such as copper (II), zinc (II), nickel (II), cobalt (II), and iron (III). The complexes formed exhibit spasmolytic activity, which can help in the treatment of various conditions related to muscle spasms and smooth muscle relaxation.
Used in Skin Care Applications:
In the field of skin care, 4-Methylumbelliferone Sodium Salt is used as an inhibitor of hyaluronan acid in cultured human skin fibroblasts. This property makes it potentially useful in the development of anti-aging and skin rejuvenation products, as it may help to regulate the production of hyaluronan, a key component of the extracellular matrix that contributes to skin hydration and elasticity.

InChI:InChI=1/C10H8O3/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5,11H,1H3

Upstream product

• 126695-25-8 methyl (4-methyl-2-oxo-2H-1-benzopyran-7-yl 4,5,7,8,9-penta-O-acetyl-3-deoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate 
• 126695-26-9 C₁₉H₂₂O₁₁ 

Downstream Products

• 28541-71-1 4′-methylumbelliferyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 
• 1228931-52-9 4-methylumbelliferyl 3,6-di-O-acetyl-2-deoxy-2-acetamido-4-O-(3,6-di-O-acetyl-2,4-dideoxy-2-acetamido-β-D-glucopyranosyl)-β-D-glucopyranoside 
• 18319-92-1 4-Methylumbelliferyl heptanoate 
• 629-62-9 pentadecane 
• 18319-93-2 4-methylumbelliferyl nonanoate 
• 20671-66-3 7-(heptylcarbonyl)oxy-4-methyl-2H-1-benzopyran-2-one 
• 59322-44-0 4--methylcoumarin--7--yl 5--acetamido--3,5--dideoxy-α---D--glycero--D--galacto-2-nonulopyranosidonic acid 
• 123269-95-4 sodium (4-methylumbelliferonyl 3-deoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate 
• 53643-13-3 4-methylumbelliferyl β-D-N,N′,N′′-triacetylchitotrioside 
• 6160-80-1 4-methylumbelliferyl-β-D-glucuronide 
• 6160-81-2 (2S,3R,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-methyl-2-oxo-2H-chromen-7-yloxy)-tetrahydro-pyran-2-carboxylic acid 
• 28541-83-5 4-methylumbellifer-7-yl α-D-mannopyranoside 
• 128095-52-3 3,4,5-trihydroxy-6-(4-methyl-2-oxo-2H-chromen-7-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 116523-82-1 methyl 4-methylcoumarin-7-yl-β-D-glucopyranuronate 

Relevant articles and documents

A Mechanistic Study on the Non-enzymatic Hydrolysis of Kdn Glycosides

Sialic acids are biologically important carbohydrates that are prevalent throughout nature. We are interested in their intrinsic reactivity in aqueous solution and how such reactivity affects the design of substrates for investigation of enzymes that process these sugars. To probe the reactivity differences between two sialic acid family members N-acetylneuraminic acid and Kdn we measured the rate constants for hydrolysis of 4-nitrophenyl 3-deoxy-d-glycero-α-d-galacto-non-2-ulosonide in aqueous solution. The kinetic data is consistent with glycosidic C?O bond cleavage occurring via four mechanistic pathways, and these are: (i) hydronium ion-catalyzed hydrolysis of the neutral sugar; (ii) hydronium ion-catalyzed hydrolysis of the glycosidic carboxylate; (iii) water-catalyzed hydrolysis of the anionic glycoside; and (iv) base-promoted reaction of the anionic glycoside. To study the effects of C-5 substitution on the Kdn glycoside we made 4-nitrophenyl 5-O-methyl-α-Kdn glycoside and determined its rate constants for hydrolysis. All hydrolytic rate constants for both Kdn glycosides were larger than those reported for the parent N-acetyl-α-neuraminide. The water-catalyzed reaction (pathway iii) exhibited a βlg value of ?1.3±0.1. We conclude that the larger rate constants associated with C5-oxygen containing sialosides results from less steric congestion at the hydrolytic transition states than for the parent C-5 acetamido glycoside.