59937-28-9 Usage
Description
Malotilate is a hepatoprotective agent that exhibits protective effects on the liver by inhibiting the metabolism of arachidonic acid to leukotriene B4 and 5-HETE in macrophages, reducing plasma levels of glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) in a rat model of liver injury, and decreasing hepatic deposition of type III procollagen, type IV collagen, laminin, and fibronectin in a rat model of hepatic fibrosis.
Used in Pharmaceutical Industry:
Malotilate is used as a hepatoprotective agent for the treatment of liver disorders such as cirrhosis and chronic hepatitis. It improves hepatic function by increasing blood and bile flow and enhancing protein synthesis.
in vitro
the in-vitro invasion assay employing a rat lung endothelial cell monolayer indicated that pretreatment of the lung endothelial cells, but not c-sst-2 cells, with malotilate reduced the invasion of the rle monolayer by c-sst-2 cells significantly. the in-vitro vascular permeability assay also demonstrated malotilate could prevent the permeability increase of the lung endothelial cell monolayer by serum starvation. in contrast, the gelatinase production and adhesion to the rle cell monolayer of c-sst-2 cells were not affected by malotilate treatment [1].
in vivo
malotilate was administered to syngeneic shr rats orally from 7 days before or after s.c. inoculation of c-sst-2 cells until the end of the experiments. in the malotilate-treated rats, pulmonary metastasis was suppressed markedly when compared with the non-treated rats. moreover, in the rats treated with malotilate for 19 days after inoculation of c-sst-2 cells, lung metastasis was also suppressed significantly [1].
references
[1] nagayasu h,hamada j,kawano t,konaka s,nakata d,shibata t,arisue m,hosokawa m,takeichi n,moriuchi t. inhibitory effects of malotilate on invasion and metastasis of rat mammary carcinoma cells by modifying the functions of vascular endothelial cells. br j cancer.1998 may;77(9):1371-7.[2] takase s,matsuda y,yasuhara m,takada a. effects of malotilate treatment on alcoholic liver disease. alcohol.1989 may-jun;6(3):219-22.
Check Digit Verification of cas no
The CAS Registry Mumber 59937-28-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,9,3 and 7 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 59937-28:
(7*5)+(6*9)+(5*9)+(4*3)+(3*7)+(2*2)+(1*8)=179
179 % 10 = 9
So 59937-28-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-8H,1-4H3
