59979-01-0

Basic information

• Product Name: 44-O-DeMethylthiocillin II
• Synonyms: 44-O-DeMethylthiocillin II;Thiocillin I
• CAS NO: 59979-01-0
• Molecular Formula: C₄₈H₄₉N₁₃O₁₀S₆
• Molecular Weight: 1160.3738
• Mol File: 59979-01-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 44-O-DeMethylthiocillin II(CAS DataBase Reference)
• NIST Chemistry Reference: 44-O-DeMethylthiocillin II(59979-01-0)
• EPA Substance Registry System: 44-O-DeMethylthiocillin II(59979-01-0)

Safety Data

• Hazardous Substances Data: 59979-01-0(Hazardous Substances Data)

Usage

Description

44-O-DeMethylthiocillin II is a derivative of the macrocyclic thiazole peptide Thiocillin I, which was first isolated from Bacillus badius. It is a simple macrocyclic thiazole peptide with a modified structure, where the methyl group at the 44th position has been removed.

Uses

Used in Pharmaceutical Industry:
44-O-DeMethylthiocillin II is used as a potent antibacterial agent for the development of new antibiotics. Its modified structure may enhance its biological activity and effectiveness against various bacterial strains.
Used in Research and Development:
44-O-DeMethylthiocillin II is used as a research compound for studying the structure-activity relationship of macrocyclic thiazole peptides and their potential applications in medicine. This can lead to the discovery of new therapeutic agents with improved properties.

Upstream product

• 253663-88-6 (4S,5R)-tert-butyl 4-(4-(6-(4-((2S,3R)-1-((R)-2-acetoxypropylamino)-3-hydroxy-1-oxobutan-2-ylcarbamoyl)-2,4'-bithiazol-2'-yl)-3-(4-((tert-butyldimethylsilyloxy)methyl)thiazol-2-yl)pyridin-2-yl)thiazol-2-yl)-5-methyl-2-oxooxazolidine-3-carboxylate 
• 253663-90-0 (4S,5R)-tert-butyl 4-(4-(6-(4-((Z)-1-((R)-2-acetoxypropylamino)-1-oxobut-2-en-2-ylcarbamoyl)-2,4'-bithiazol-2'-yl)-3-(4-formylthiazol-2-yl)pyridin-2-yl)thiazol-2-yl)-5-methyl-2-oxooxazolidine-3-carboxylate 
• 253663-66-0 C₁₂H₁₈N₂O₅S 
• 31825-95-3 2-methylthiazole-4-carboxamide 
• 1174675-84-3 ethyl 2'-(1-hydroxyprop-2-ynyl)-2,4'-bithiazole-4-carboxylate 
• 1174675-85-4 ethyl 2'-propioloyl-2,4'-bithiazole-4-carboxylate 
• 1174675-88-7 ethyl 2'-(5-(4-(acetoxymethyl)thiazol-2-yl)-6-(2-((4S,5R)-5-methyl-2-oxooxazolidin-4-yl)thiazol-4-yl)pyridin-2-yl)-2,4'-bithiazole-4-carboxylate 
• 174223-30-4 ethyl 2'-methyl-2,4'-bithiazole-4-carboxylate 
• 6436-59-5 ethyl 2-methylthiazole-4-carboxylate 
• 1285679-98-2 (S)-methyl 2-[1-(tert-butoxycarbonylamino)-2-hydroxy-2-methylpropyl]thiazole-4-carboxylate 
• 1285680-00-3 C₂HF₃O₂*C₉H₁₄N₂O₃S 
• 1285680-05-8 (S)-methyl 2-((R)-1-(2-((1S,2R)-1-(tert-butoxycarbonylamino)-2-hydroxypropyl)thiazole-4-carboxamido)-2-hydroxy-2-methylpropyl)thiazole-4-carboxylate 
• 1285680-06-9 C₂₈H₄₁N₅O₉S₂ 
• 1285680-08-1 (4S,5R)-tert-butyl 4-((Z)-1-(4((R)-2-hydroxy-1-(4-(methoxycarbonyl)thiazol-2-yl)-2-methylpropylcarbamoyl)thiazol-2-yl)prop-1-enylcarbamoyl)-2,2,5-trimethyloxazolidine-3-carboxylate 

Relevant articles and documents

Total synthesis of micrococcin P1 and thiocillin I enabled by Mo(vi) catalyst

Thiopeptides are a class of potent antibiotics with promising therapeutic potential. We developed a novel Mo(vi)-oxide/picolinic acid catalyst for the cyclodehydration of cysteine peptides to form thiazoline heterocycles. With this powerful tool in hand,