60010-78-8

Basic information

• Product Name: (2R,3R,4R)-4-Hydroxyisoleucine
• Synonyms: (2R,3R,4R)-4-Hydroxyisoleucine;(4R)-4-Hydroxy-D-alloisoleucine
• CAS NO: 60010-78-8
• Molecular Formula: C6H13NO3
• Molecular Weight: 147.17232
• Mol File: 60010-78-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 331.6±32.0 °C(Predicted)
• Appearance: /
• Density: 1.181
• PKA: 2.41±0.25(Predicted)
• CAS DataBase Reference: (2R,3R,4R)-4-Hydroxyisoleucine(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R,4R)-4-Hydroxyisoleucine(60010-78-8)
• EPA Substance Registry System: (2R,3R,4R)-4-Hydroxyisoleucine(60010-78-8)

Safety Data

• Hazardous Substances Data: 60010-78-8(Hazardous Substances Data)

Usage

Description

(2R,3R,4R)-4-Hydroxyisoleucine is a natural compound found in the fenugreek plant (Trigonella foenum-graecum) and is a derivative of the amino acid isoleucine. It possesses potential medicinal properties and has been studied for its various health benefits.
Used in Pharmaceutical Industry:
(2R,3R,4-Hydroxyisoleucine is used as a potential treatment for diabetes for its ability to lower blood sugar levels and improve insulin sensitivity.
Used in Sports Nutrition Industry:
(2R,3R,4-Hydroxyisoleucine is used as a supplement for muscle growth and athletic performance enhancement due to its potential to modulate glucose metabolism and induce insulin release.
Used in Skincare Industry:
(2R,3R,4-Hydroxyisoleucine is used as an ingredient in skincare products for its antioxidant and anti-inflammatory properties, making it a promising candidate for therapeutic use in managing metabolic disorders and promoting skin health.

Upstream product

• 75-24-1 trimethylaluminum 
• 115983-56-7 benzyl 2,3-anhydro-4-O-(tert-butyldimethylsilyl)-β-L-ribopyranoside 

Relevant articles and documents

Method for preparing diastereoisomers of 4-hydroxy isoleucine

The invention relates to a method for preparing diastereoisomers of 4-hydroxy isoleucine of formula A ????????CO2H- CH(NH2)- CH(CH3)-CH(OH)-CH3?????(A) which comprises the following steps: deprotection of amine of Formula B reduction and subsequent lactonisation of an intermediate amine derivative of formula C whose substituents at positions 2 and 3 are either R, S or S, S ; or S, R or R, R,hydrolysis of the resulting lactone of formula D where in substituents at positions 2, 3 and 4 are S,R,S or S,R,R when using a protected amine S,RS,S,S or S,S,R when using a protected amine S,SR,S,R or R,S,S, when using a protected amine R,SR,R,R or R,R,S when using a protected amine R,R under conditions to obtain the desired isomer of 4-hydroxy isoleucine. Application for preparing the 8 isomeric forms of 4-hydroxy isoleucine.

DIASTEREOISOMERS OF 4-HYDROXYISOLEUCINE AND USES THEREOF

The invention relates to configurational isomers 4-hydroxyisoleucine, and to lactones, pharmaceutically acceptable salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. The isomers of the invention exhibit insulinotropic activity and thus may be useful for the prevention and treatment of disorders of carbohydrate or lipid metabolism, including diabetes mellitus (type 1 and type 2 diabetes), pre-diabetes, and Metabolic Syndrome.