602314-57-8

Basic information

• Product Name: 4-Isoxazolol, 4,5-dihydro-3-(1-methylethyl)-5-phenyl-, (4S,5R)-
• CAS NO: 602314-57-8
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Mol File: 602314-57-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Isoxazolol, 4,5-dihydro-3-(1-methylethyl)-5-phenyl-, (4S,5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isoxazolol, 4,5-dihydro-3-(1-methylethyl)-5-phenyl-, (4S,5R)-(602314-57-8)
• EPA Substance Registry System: 4-Isoxazolol, 4,5-dihydro-3-(1-methylethyl)-5-phenyl-, (4S,5R)-(602314-57-8)

Safety Data

• Hazardous Substances Data: 602314-57-8(Hazardous Substances Data)

Upstream product

• 177314-50-0 trans-(1S,2R)-1,2-epoxy-4-methyl-1-phenylpentan-3-one 

Downstream Products

• 93-56-1 phenylethane 1,2-diol 
• 1492-15-5 (S)-N-acetylvaline methyl ester 

Relevant articles and documents

Stereocontrolled conversion of some optically active (4S,5R)-dihydroisoxazoles into acyclic 3-acetamido-1,2-diols

Optically active (4S,5R)-dihydroisoxazoles 5a-c (90-91% ee) have been prepared by reaction of the epoxyketones 4a-c with hydroxylamine. Reduction of compounds 5a and 5b using lithium aluminium hydride took place exclusively from the Re face to give (1R,2S,3S)-1,3-disubstituted-3-aminopropane-1,2-diols 6a and 6b. These amino-diols were characterised by N-acetylation and the stereochemical sense of the hydride reduction was confirmed by conversion of amides 7a and 7b into α-amino acid derivatives 10a and 10b.