60274-60-4Relevant articles and documents
New 1-benzyl-4-hydroxypiperidine derivatives as non-imidazole histamine H3 receptor antagonists
Maslowska-Lipowicz, Iwona,Figlus, Marek,Zuiderveld, Obbe P.,Walczynski, Krzysztof
body text, p. 762 - 773 (2009/05/07)
A series of 1-benzyl-4-(3-aminopropyloxy)piperidine and 1-benzyl-4-(5-aminopentyloxy)piperidine derivatives has been prepared. The 1-benzyl-4-hydroxypiperidine derivatives obtained were evaluated for their affinities at recombinant human histamine H3 receptor, stably expressed in HEK 293T cells. All compounds investigated show moderate to pronounced in-vitro affinities. The most potent antagonists in this series 9b2 (hH3R, pKi = 7.09), 9b1 (hH3R, pKi = 6.78), 9b5 (hH3R, pKi = 6.99), and 9b6 (hH3R, pKi = 6.97) were also tested in vitro as H3 receptor antagonists - the electrically evoked contraction of the guinea-pig jejunum. The histaminergic H1 antagonism of selected compounds 9b1, 9b2, and 9b4-9b6 was established on the isolated guinea-pig ileum by conventional methods; the pA2 values were compared with the potency of pyrilamine. The compounds did not show any H1 antagonistic activity (pA 2 2 = 9.53).
A Mild and Convenient Procedure for Conversion of Alkenes into Alkyl Iodides via Reaction of Iodine Monochloride with Organoboranes
Kabalka, George W.,Gooch, Eugene E.
, p. 3578 - 3580 (2007/10/02)
Alkenes are rapidly converted to alkyl iodides under mild conditions via a hydroboration-iodination sequence which utilizes iodine monochloride as the iodination agent.The iodination proceeds with inversion of configuration.A series of functionally substituted iodides was synthesized via the new products.